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Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
Journal of Orthopaedic Research®, 36 (2017), 6; 1684-1693. https://doi.org/10.1002/jor.23823
Vrgoč, Goran; Vrbanec, Jurica; Eftedal, Randi K.; Dembić, Petra L.; Balen, Sanja; Dembić, Zlatko; Jotanović, Zdravko

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Vrgoč, G., Vrbanec, J., Eftedal, R. K., Dembić, P. L., Balen, S., Dembić, Z. i Jotanović, Z. (2017). Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research®, 36. (6), 1684-1693. doi: 10.1002/jor.23823

Vrgoč, Goran, et al. "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis." Journal of Orthopaedic Research®, vol. 36, br. 6, 2017, str. 1684-1693. https://doi.org/10.1002/jor.23823

Vrgoč, Goran, Jurica Vrbanec, Randi K. Eftedal, Petra L. Dembić, Sanja Balen, Zlatko Dembić i Zdravko Jotanović. "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis." Journal of Orthopaedic Research® 36, br. 6 (2017): 1684-1693. https://doi.org/10.1002/jor.23823

Vrgoč, G., et al. (2017) 'Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis', Journal of Orthopaedic Research®, 36(6), str. 1684-1693. doi: 10.1002/jor.23823

Vrgoč G, Vrbanec J, Eftedal RK, Dembić PL, Balen S, Dembić Z, i sur.. Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research® [Internet]. 2017. [pristupljeno 25.10.2024.];36(6):1684-1693. doi: 10.1002/jor.23823

G. Vrgoč, et al., "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis", Journal of Orthopaedic Research®, vol. 36, br. 6, str. 1684-1693, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:358497. [Citirano: 25.10.2024.]

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Podaci o radu
Naslov (engleski)Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
AutorGoran Vrgoč
AutorJurica Vrbanec
AutorRandi K. Eftedal
AutorPetra L. Dembić
AutorSanja Balen
MBZ: 236875
AutorZlatko Dembić
AutorZdravko Jotanović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ortopediju i fizikalnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Primary osteoarthritis (OA) is the most common type of a joint disease. It has a polygenic risk inheritance pattern and affects older people. The etiology of this disease is not fully understood. The aim of this study was to investigate the associations between polymorphisms in pro‐ inflammatory interleukin‐17 (IL17A and IL17F) and anti‐inflammatory Toll‐like Receptor 10 (TLR10) genes with the risk for development of advanced stage hip and knee primary OA in the Croatian population. A total of 500 OA patients and 597 controls were genotyped for IL17A SNP (rs2275913), IL17F SNPs (rs763780 and rs1889570), and TLR10 (rs11096957) genes. The allelic and genotypic frequencies of IL17F SNP (rs763780) showed statistically significant differences in comparisons of controls with hip—but not knee—OA patients. The major allele (T) of rs763780 was associated with the lower risk for developing hip OA (p = 7.9 × 10−4, OR = 0.45, 95%CI = 0.27– 0.74), whereas the minor allele (C) was associated with susceptibility to hip OA (p = 7.9 × 10−4, OR = 2.24, 95%CI = 1.35–3.72). The genotype T/T was associated with the protection to hip OA (p = 3.9 × 10−4, OR = 0.41, 95%CI = 0.24–0.70), and, lastly, the genotype T/C was associated with the higher risk to acquiring hip OA (p = 2.6 × 10−4, OR = 2.50, 95%CI = 1.47– 4.25). TLR10 SNP rs11096957 was found significantly associated with predisposition to hip OA (p = 0.04, OR = 1.41, 95%CI = 1.02–1.94) but not knee OA. Our findings suggest that hip OA in Croatian population might have a different genetic risk regarding the IL17 and TLR10 gene locus than knee OA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Orthopaedic Research®
Brojčani podacivol. 36, br. 6, str. 1684-1693
p-ISSN0736-0266
DOIhttps://doi.org/10.1002/jor.23823
URN:NBNurn:nbn:hr:184:358497
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/1047290
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-23 16:24:11