prikaz prve stranice dokumenta Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
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Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
Journal of diabetes and its complications, 30 (2016), 7; 1347-1353. urn:nbn:hr:184:988283
Mikolašević, Ivana; Milić, Sandra; Orlić, Lidija; Štimac, Davor; Franjić, Neven; Targher, Giovanni

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Mikolašević, I., Milić, S., Orlić, L., Štimac, D., Franjić, N. i Targher, G. (2016). Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome. Journal of diabetes and its complications, 30. (7), 1347-1353. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, Ivana, et al. "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome." Journal of diabetes and its complications, vol. 30, br. 7, 2016, str. 1347-1353. https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, Ivana, Sandra Milić, Lidija Orlić, Davor Štimac, Neven Franjić i Giovanni Targher. "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome." Journal of diabetes and its complications 30, br. 7 (2016): 1347-1353. https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, I., et al. (2016) 'Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome', Journal of diabetes and its complications, 30(7), str. 1347-1353. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:988283 (Datum pristupa: 14.11.2024.)

Mikolašević I, Milić S, Orlić L, Štimac D, Franjić N, Targher G. Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome. Journal of diabetes and its complications [Internet]. 2016. [pristupljeno 14.11.2024.];30(7):1347-1353. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:988283

I. Mikolašević, S. Milić, L. Orlić, D. Štimac, N. Franjić i G. Targher, "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome", Journal of diabetes and its complications, vol. 30, br. 7, str. 1347-1353, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:988283. [Citirano: 14.11.2024.]

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Naslov (engleski)Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
AutorIvana Mikolašević
AutorSandra Milić
AutorLidija Orlić
AutorDavor Štimac
AutorNeven Franjić
AutorGiovanni Targher
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background/Aims: We examined the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM), as assessed by transient elastography (TE), and different clinical and biochemical parameters in patients with one or more components of the metabolic syndrome (MetS). The hypothesis of the study was that LSM and CAP values correlate with the number of MetS components. Methods: In this cross-sectional study a total of 648 consecutive patients were recruited during the years 2013-2015. Significant liver steatosis was defined as a CAP value≥238 dB/m, whereas significant fibrosis was defined as a LSM value>7.0 kPa. Results: The prevalence of patients with CAP≥238 dB/m and LSM>7.0 kPa were 88.3% and 16.5%, respectively. Patients with CAP≥238 dB/m (n=572) had a markedly higher prevalence of the MetS and all its individual components, as well as higher levels of serum liver enzymes and uric acid compared with those with normal CAP. Moreover, CAP measurements increased progressively with the number of MetS components. Similarly, among patients with CAP≥238 dB/m, those with LSM>7.0 kPa (n=103) had higher serum liver enzymes and a greater prevalence of the MetS and its individual components than those with LSM≤7.0 kPa. In multivariable regression analysis the factors independently associated with elevated CAP were the presence of the MetS (or its individual components), insulin resistance (defined by HOMA-IR score), increased serum uric acid and LSM>7 kPa. Similarly, the MetS (or its individual components), insulin resistance and increased serum uric acid levels were also independently associated with LSM>7.0 kPa. Conclusions: Patients with one or more MetS components have a high prevalence of NAFLD and advanced liver fibrosis. LSM and CAP correlate with the number of MetS components.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of diabetes and its complications
Brojčani podacivol. 30, br. 7, str. 1347-1353
p-ISSN1056-8727
URN:NBNurn:nbn:hr:184:988283
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/815883
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2022-02-18 14:24:05