prikaz prve stranice dokumenta Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
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Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
Biomedical Reports, 16 (2021), 2; 12. https://doi.org/10.3892/br.2021.1495
Čizmarević, Nada; Ćurko‑Cofek, Božena; Barac-Latas, Vesna; Peterlin, Borut; Ristić, Smiljana

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Čizmarević, N., Ćurko‑Cofek, B., Barac Latas, V., Peterlin, B. i Ristić, S. (2021). Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis. Biomedical Reports, 16. (2). doi: 10.3892/br.2021.1495

Čizmarević, Nada, et al. "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis." Biomedical Reports, vol. 16, br. 2, 2021. https://doi.org/10.3892/br.2021.1495

Čizmarević, Nada, Božena Ćurko‑Cofek, Vesna Barac Latas, Borut Peterlin i Smiljana Ristić. "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis." Biomedical Reports 16, br. 2 (2021). https://doi.org/10.3892/br.2021.1495

Čizmarević, N., et al. (2021) 'Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis', Biomedical Reports, 16(2). doi: 10.3892/br.2021.1495

Čizmarević N, Ćurko‑Cofek B, Barac Latas V, Peterlin B, Ristić S. Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis. Biomedical Reports [Internet]. 17.12.2021. [pristupljeno 19.11.2024.];16(2). doi: 10.3892/br.2021.1495

N. Čizmarević, B. Ćurko‑Cofek, V. Barac Latas, B. Peterlin i S. Ristić, "Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis", Biomedical Reports, vol. 16, br. 2, Prosinac 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:609991. [Citirano: 19.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:609991
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Podaci o radu
Naslov (engleski)Lack of association between C282Y and H63D polymorphisms in the hemochromatosis gene and risk of multiple sclerosis: A meta‑analysis
AutorNada Čizmarević
AutorBožena Ćurko‑Cofek
AutorVesna Barac-Latas
AutorBorut Peterlin
AutorSmiljana Ristić
MBZ: 142283
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Increasing evidence supports the potential role of iron metabolism in multiple sclerosis (MS). Previous studies examining the association between polymorphisms of the hemochromatosis gene (HFE) and susceptibility to MS have yielded inconsistent results. In the present study, a meta‑anal‑ ysis of 7 studies was performed conducted in populations of Caucasian origin using the Comprehensive Meta‑analysis 3.0 software. The strength of association between the C282Y and H63D polymorphisms in HFE and MS risk was estimated by odds ratios with 95% confidence intervals. Cochran's Q statistic and I2 tests were applied to quantify heterogeneity between studies. An Egger's test was used to estimate publication bias. The C282Y and H63D polymorphisms had no significant asso‑ ciation with increased MS risk (all P≥0.05) in the following genetic comparison models: Dominant model (YY + CY vs. CC or DD + HD vs. HH) and allele contrast (Y vs. C or D vs. H). No apparent publication bias or significant heteroge‑ neity was found between studies. These results suggest that the HFE polymorphisms C282Y and H63D are not associated with susceptibility to MS in populations of Caucasian origin. Further studies should be performed in a larger series of MS patients to evaluate the contribution of HFE and other genetic variants associated with iron regulation in the development and progression of MS
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedical Reports
Brojčani podacivol. 16, br. 2, 12
p-ISSN2049-9434
e-ISSN2049-9442
DOIhttps://doi.org/10.3892/br.2021.1495
URN:NBNurn:nbn:hr:184:609991
Datum objave publikacije2021-12-17
ProjektŠifra: uniri-biomed-18-137
Naziv (hrvatski): Farmakogenetika multiple skleroze:odgovor na imunomodulacijsku terapiju
Naziv (engleski): Farmacogenetics of multiple sclerosis: response to disease-modifying therapy
Voditelj: Nada Starčević Čizmarević
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttp://www.spandidos-publications.com/10.3892/br.2021.1495
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2022-06-17
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-02-01 12:06:16