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IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
Cancers, 13 (2021), 17; 4306. https://doi.org/10.3390/cancers13174306
Maržić, Diana; Marijić, Blažen; Braut, Tamara; Janik, Stefan; Avirović, Manuela; Hadžisejdić, Ita; Tudor, Filip; Radobuljac, Katarina; Čoklo, Miran; Erovic, Boban M.

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Maržić, D., Marijić, B., Braut, T., Janik, S., Avirović, M., Hadžisejdić, I. ... Erovic, B. M. (2021). IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers, 13. (17). doi: 10.3390/cancers13174306

Maržić, Diana, et al. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers, vol. 13, br. 17, 2021. https://doi.org/10.3390/cancers13174306

Maržić, Diana, Blažen Marijić, Tamara Braut, Stefan Janik, Manuela Avirović, Ita Hadžisejdić, Filip Tudor, Katarina Radobuljac, Miran Čoklo i Boban M. Erovic. "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma." Cancers 13, br. 17 (2021). https://doi.org/10.3390/cancers13174306

Maržić, D., et al. (2021) 'IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma', Cancers, 13(17). doi: 10.3390/cancers13174306

Maržić D, Marijić B, Braut T, Janik S, Avirović M, Hadžisejdić I, i sur.. IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma. Cancers [Internet]. 26.08.2021. [pristupljeno 24.12.2024.];13(17). doi: 10.3390/cancers13174306

D. Maržić, et al., "IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma", Cancers, vol. 13, br. 17, Kolovoz 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:958258. [Citirano: 24.12.2024.]

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Podaci o radu
Naslov (engleski)IMP3 Protein Overexpression Is Linked to Unfavorable Outcome in Laryngeal Squamous Cell Carcinoma
AutorDiana Maržić
AutorBlažen Marijić
AutorTamara Braut
AutorStefan Janik
AutorManuela Avirović
AutorIta Hadžisejdić
AutorFilip Tudor https://orcid.org/0000-0001-6386-0444
AutorKatarina Radobuljac
AutorMiran Čoklo
AutorBoban M. Erovic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za otorinolaringologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Background: The aim of this study was to (i) determine IMP3 protein expression in benign and malignant laryngeal lesions, (ii) compare its expression to Ki-67, p53, cyclin D1, and (iii) finally, to examine the prognostic power of IMP3 in squamous cell carcinomas of the larynx (LSSC). Methods: IMP3 protein expression was evaluated in 145 patients, including 62 LSCC, 45 dysplasia (25 with low and 20 with high-grade dysplasia), and 38 benign lesions (vocal cord polyps and nodules). Results: IMP3 was significantly higher expressed in LSCC compared to dysplasia and benign lesions (p < 0.001; p < 0.001, respectively). Similarly, higher expression patterns were observed for Ki-67 and p53, whereas cyclin D1 was equally distributed in all three lesions. IMP3 (p = 0.04) and Ki-67 (p = 0.02) expressions were significantly linked to neck node positivity, and IMP3 overexpression to worse disease-specific survival (p = 0.027). Conclusion: Since IMP3 showed significantly higher expression in laryngeal carcinomas, but not in high- or low-grade dysplasia, it serves as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression represented a significantly worse prognosticator for clinical outcomes of patients with squamous cell carcinoma of the larynx.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 13, br. 17, 4306
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13174306
URN:NBNurn:nbn:hr:184:958258
Datum objave publikacije2021-08-26
ProjektŠifra: uniri-biomed-18-121
Naziv (hrvatski): Molekularni biomarkeri kancerogeneze u skvamoznim epitelnim lezijama grkljana
Naziv (engleski): Molecular biomarkers of cancerogenesis in laryngeal squamous epithelial lesions
Voditelj: Tamara Braut
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: uniri-biomed-18-242
Naziv (hrvatski): Klinički značaj niske razine JAK2 V617F mutacije u perifernoj krvi: utjecaj na fenotip i prognozu
Naziv (engleski): Clinical significance of low level JAK2 V617F mutation in peripheral blood: effect on phenotype and prognosis
Voditelj: Ita Hadžisejdić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttps://www.mdpi.com/2072-6694/13/17/4306
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2021-10-26 12:13:04