Malignant diseases are pathological formations caused by the malignant transformation of healthy cells that treat the host parasitically. They are the leading cause of death today, and improved diagnostics contribute to the steady increase in incidence. The strongest link in the fight against cancer are primary care physicians. They are active in all stages of treatment of cancer patients and represent the greatest psychosocial support to the patients and their families. Healthcare systems that nurture a multidisciplinary approach to the oncology patient, with a primary care physician at the helm, record the best therapeutic successes. In addition to their curative role, primary care physicians are at the forefront of disease prevention holding the greatest role in preventing cancer development. This is done by promoting primary prevention measures by encouraging their patients to avoid carcinogens and by presenting National Cancer Early Detection Programs, resulting in a better response among targeted populations. The aim of this paper is to point out the benefits of primary and secondary measures for the prevention of malignant neoplasms, promote the model of oncology care with the active involvement of primary care physicians and emphasize the importance of palliative care for terminal patients who deserve a dignified death free of suffering and pain.