prikaz prve stranice dokumenta Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies
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Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies
Journal of Virological Methods, 293 (2021); 114173. https://doi.org/10.1016/j.jviromet.2021.114173
Bubonja-Šonje, Marina; Batičić, Lara; Abram, Maja; Cekinović Grbeša, Đurđica

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Bubonja Šonje, M., Batičić, L., Abram, M. i Cekinović Grbeša, Đ. (2021). Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies. Journal of Virological Methods, 293.. doi: 10.1016/j.jviromet.2021.114173

Bubonja Šonje, Marina, et al. "Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies." Journal of Virological Methods, vol. 293, 2021. https://doi.org/10.1016/j.jviromet.2021.114173

Bubonja Šonje, Marina, Lara Batičić, Maja Abram i Đurđica Cekinović Grbeša. "Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies." Journal of Virological Methods 293 (2021). https://doi.org/10.1016/j.jviromet.2021.114173

Bubonja Šonje, M., et al. (2021) 'Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies', Journal of Virological Methods, 293. doi: 10.1016/j.jviromet.2021.114173

Bubonja Šonje M, Batičić L, Abram M, Cekinović Grbeša Đ. Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies. Journal of Virological Methods [Internet]. 27.04.2021. [pristupljeno 04.12.2024.];293. doi: 10.1016/j.jviromet.2021.114173

M. Bubonja Šonje, L. Batičić, M. Abram i Đ. Cekinović Grbeša, "Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies", Journal of Virological Methods, vol. 293, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:242267. [Citirano: 04.12.2024.]

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Naslov (engleski)Diagnostic accuracy of three SARS-CoV2 antibody detection assays, neutralizing effect and longevity of serum antibodies
AutorMarina Bubonja-Šonje
AutorLara Batičić
AutorMaja Abram
AutorĐurđica Cekinović Grbeša
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička imunologija
Sažetak (engleski)
Evidence is currently insufficient to know whether SARS-CoV-2 antibodies (Abs) protect from future infection and how long immunity will last. The kinetics of the immune response to SARS-CoV-2 infection and role of serology in estimating individual protective immunity is yet to be established. We evaluated diagnostic performances of three serological assays - Abbott Architect CMIA IgG, bioMerieux VIDAS ELFA IgG/IgM, and Diesse Chorus ELISA IgG/IgM, and analyzed longevity and potential neutralizing effect of SARS-CoV-2 Abs in COVID-19 patients. Clinical sensitivities of assessed IgG tests two to three weeks post symptom onset (PSO) were very high: 96.77 % for Architect, 96.77 % for Chorus, and 100.00 % for VIDAS. Sensitivities of two assessed IgM assays were moderate: 74.07 % for Chorus, and 76.92 % for VIDAS. Specificities were excellent for all assessed IgG assays: 99.01 % for Architect and 100 % for Chorus and VIDAS. Chorus and VIDAS IgM assays also achieved excellent specificity of 99.01 % and 100 %, respectively. In most cases IgG Abs were still present eight months PSO. Neutralizing antibodies were detected in majority of serum samples from convalescent patients. Serum samples from severe COVID-19 patients had higher antibody titers and higher neutralizing activity. We observed a strong positive correlation among SARS-CoV-2 IgG antibody titer and neutralizing activity. The strongest positive correlation to neutralizing activity was found for VIDAS IgG assay.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virological Methods
Brojčani podacivol. 293, 114173
p-ISSN0166-0934
DOIhttps://doi.org/10.1016/j.jviromet.2021.114173
URN:NBNurn:nbn:hr:184:242267
Datum objave publikacije2021-04-27
ProjektŠifra: uniri-biomed-18-277
Naziv (hrvatski): Bakterijska patogeneza - od istraživanja do kliničke primjene
Voditelj: Maja Abram
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0166093421001129
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-05-13 19:57:48