Diabetes mellitus or diabetes is a set of disorders of the metabolism of carbohydrates, fats and proteins in the body. It is a significant public health problem because it is one of the ten leading causes of death in the world. The disease is divided into type I, type II, gestational diabetes and other, less common types of diabetes. Diabetes is accompanied by many complications, such as delayed wound healing. Many scientific papers prove and emphasize the importance of proteases in the wound healing process. The wound healing process in diabetes is hampered by a number of factors. Wound healing is a process that takes place in several interrelated stages. Dipeptidyl peptidase IV, or CD26 molecule, is a multifunctional protein that plays a very important role in maintaining blood glucose homeostasis. It also has a very important role in pathophysiological and physiological processes. The DPP IV / CD26 molecule is expressed on mature thymocytes, active T, B lymphocytes, NK cells, and macrophages and a number of cells such as epithelial, endothelial cells of various organs and tissues. DPP IV / CD26 is known to participate in cell adhesion, migration and apoptosis, degradation of the extracellular matrix of cells and key processes in wound healing, where it acts as an inflammatory mediator and promotes reepitalization of injured tissue. The function of DPP IV / CD26 is twofold; its proteolytic function affects various substrates involved in the wound healing process and participates in the modulation and stimulation of the immune response in the wound healing process.