prikaz prve stranice dokumenta Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity
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Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity
Obesity Medicine, 20 (2020); 100302. https://doi.org/10.1016/j.obmed.2020.100302
Belančić, Andrej

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Belančić, A. (2020). Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity. Obesity Medicine, 20., 100302. doi: 10.1016/j.obmed.2020.100302

Belančić, Andrej. "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity." Obesity Medicine, vol. 20, 2020, str. 100302. https://doi.org/10.1016/j.obmed.2020.100302

Belančić, Andrej. "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity." Obesity Medicine 20 (2020): 100302. https://doi.org/10.1016/j.obmed.2020.100302

Belančić, A. (2020) 'Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity', Obesity Medicine, 20, str. 100302. doi: 10.1016/j.obmed.2020.100302

Belančić A. Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity. Obesity Medicine [Internet]. 12.2020. [pristupljeno 17.06.2024.];20:100302. doi: 10.1016/j.obmed.2020.100302

A. Belančić, "Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity", Obesity Medicine, vol. 20, str. 100302, Prosinac 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:776025. [Citirano: 17.06.2024.]

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Podaci o radu
Naslov (engleski)Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity
AutorAndrej Belančić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The overall intestinal lipopolysaccharide (LPS) composition in the individuals with obesity could be shifted away from immunosilent/immunoinhibitory Bacteroidetes LPS subtypes, in favor of various proinflammatory LPS subtypes due to gut microbiome dysbiosis. What is more, high-fat diet, as well as obesity per se, enhance intestinal permeability through various mechanisms. Latter results in increased paracellular absorption and transcellular (via chylomicrons) transport of endogenous endotoxin in the circulatory system (endotoxemia). In addition, it is known that lipid A initiates a signaling cascade resulting in activation of various proinflammatory pathways and increases oxidative stress upon binding to tool-like receptor 4 (TLR4). Taking everything into consideration, it is very likely that gut microbiome dysbiosis and endotoxemia represent the additional pathophysiological explanation for increased COVID-19 severity in obesity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaObesity Medicine
Brojčani podacivol. 20, str. 100302, 100302
p-ISSN2451-8476
DOIhttps://doi.org/10.1016/j.obmed.2020.100302
URN:NBNurn:nbn:hr:184:776025
Datum objave publikacije2020-12
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2451847620301226
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-01-06 19:45:58