In persons´ life, many situation cause stressful stimulus which is called psychological stress. This stimulus, trough the neuroendocrine and immune systems, affects many organs in our body and disrupts homeostasis thus leads into onset of certain diseases that are called psychosomatic diseases. Some of the most common ones are hypertension, gastric ulcer, irritable colon, various dermatological diseases, and some types of cancer but the exact pathophysiological process is unknown. In order for a situation to lead to an organism's reactions in the form of a general adaptation syndrome, the situation must be assessed as loss, challenge or threat, and for this the assessment of situation is needed. The primary assessment estimates whether the upcoming situation is endangering for individual, and secondary assessment evaluates what can be done to reduce negative influence of situation on persons integrity. If the situation is assessed as threating it must be adequately confronted. There are three ways to affront with stress stimuli: focus on problem, focus on emotion or avoid the stimulus. Depending on which of the confront ways person chose, the behavior of person or ambience changes, or the affect that are caused by stress stimulus changes, or person does not acknowledge that this event is happening and proceeds as if nothing had happened. People who do not have adequate way of coping with problems, perform worse in society, its life moral is more negative, and they are susceptible o psychosomatic diseases. So, the role of general practitioner is to recognize, educate and helping people who can not cope with stress, encourage to change former lifestyle and treat diseases that have arisen under the influence of long-term stress.