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Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury
Journal of Neuropathology & Experimental Neurology, 79 (2020), 11; 1163-1182. https://doi.org/10.1093/jnen/nlaa111
Dolenec, Petra; Pilipović, Kristina; Janković, Tamara; Župan, Gordana

Citirajte ovaj rad

Dolenec, P., Pilipović, K., Janković, T. i Župan, G. (2020). Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury. Journal of Neuropathology & Experimental Neurology, 79. (11), 1163-1182. doi: 10.1093/jnen/nlaa111

Dolenec, Petra, et al. "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury." Journal of Neuropathology & Experimental Neurology, vol. 79, br. 11, 2020, str. 1163-1182. https://doi.org/10.1093/jnen/nlaa111

Dolenec, Petra, Kristina Pilipović, Tamara Janković i Gordana Župan. "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury." Journal of Neuropathology & Experimental Neurology 79, br. 11 (2020): 1163-1182. https://doi.org/10.1093/jnen/nlaa111

Dolenec, P., et al. (2020) 'Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury', Journal of Neuropathology & Experimental Neurology, 79(11), str. 1163-1182. doi: 10.1093/jnen/nlaa111

Dolenec P, Pilipović K, Janković T, Župan G. Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury. Journal of Neuropathology & Experimental Neurology [Internet]. 01.11.2020. [pristupljeno 07.12.2024.];79(11):1163-1182. doi: 10.1093/jnen/nlaa111

P. Dolenec, K. Pilipović, T. Janković i G. Župan, "Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury", Journal of Neuropathology & Experimental Neurology, vol. 79, br. 11, str. 1163-1182, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:812626. [Citirano: 07.12.2024.]

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Naslov (engleski)Pattern of Neuronal and Axonal Damage, Glial Response, and Synaptic Changes in Rat Cerebellum within the First Week following Traumatic Brain Injury
AutorPetra Dolenec
AutorKristina Pilipović
AutorTamara Janković
AutorGordana Župan
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Abstract We examined damage and repair processes in the rat cerebellum within the first week following moderate traumatic brain injury (TBI) induced by lateral fluid percussion injury (LFPI) over the left parietal cortex. Rats were killed 1, 3, or 7 days after the injury or sham procedure. Fluoro-Jade B staining revealed 2 phases of neurodegenerative changes in the cell bodies and fibers: first, more focal, 1 day after the LFPI, and second, widespread, starting on post-injury day 3. Purkinje cell loss was detected in posterior lobule IX 1 day following LFPI. Apoptosis was observed in the cerebellar cortex, on days 1 and 7 following LFPI, and was not caspase- or apoptosis-inducing factor (AIF)-mediated. AIF immunostaining indicated axonal damage in the cerebellar white matter tracts 3- and 7-days post-injury. Significant astrocytosis and microgliosis were noticed on day 7 following LFPI at the sites of neuronal damage and loss. Immunohistochemical labeling with the presynaptic markers synaptophysin and growth-associated protein-43 revealed synaptic perturbations already on day 1 that were more pronounced at later time points following LFPI. These results provide new insights into pathophysiological alterations in the cerebellum and their mechanisms following cerebral TBI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Neuropathology & Experimental Neurology
Brojčani podacivol. 79, br. 11, str. 1163-1182
p-ISSN0022-3069
e-ISSN1554-6578
DOIhttps://doi.org/10.1093/jnen/nlaa111
URN:NBNurn:nbn:hr:184:812626
Datum objave publikacije2020-11-01
ProjektŠifra: 062-0620529-0519
Naziv (hrvatski): Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija
Voditelj: Gordana Župan
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://academic.oup.com/jnen/article/79/11/1163/5924443
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2020-11-03 13:25:39