prikaz prve stranice dokumenta Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
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Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
Indian Journal of Medical Research, 150 (2019), 1; 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17
Šustar, Aleksandra; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Švob Štrac, Dubravka; Pivac, Nela

Citirajte ovaj rad

Šustar, A., Nikolac Perković, M., Nedić Erjavec, G., Švob Štrac, D. i Pivac, N. (2019). Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease. Indian Journal of Medical Research, 150. (1), 43-49. doi: 10.4103/ijmr.IJMR_1566_17

Šustar, Aleksandra, et al. "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease." Indian Journal of Medical Research, vol. 150, br. 1, 2019, str. 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17

Šustar, Aleksandra, Matea Nikolac Perković, Gordana Nedić Erjavec, Dubravka Švob Štrac i Nela Pivac. "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease." Indian Journal of Medical Research 150, br. 1 (2019): 43-49. https://doi.org/10.4103/ijmr.IJMR_1566_17

Šustar, A., et al. (2019) 'Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease', Indian Journal of Medical Research, 150(1), str. 43-49. doi: 10.4103/ijmr.IJMR_1566_17

Šustar A, Nikolac Perković M, Nedić Erjavec G, Švob Štrac D, Pivac N. Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease. Indian Journal of Medical Research [Internet]. 2019. [pristupljeno 19.11.2024.];150(1):43-49. doi: 10.4103/ijmr.IJMR_1566_17

A. Šustar, M. Nikolac Perković, G. Nedić Erjavec, D. Švob Štrac i N. Pivac, "Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease", Indian Journal of Medical Research, vol. 150, br. 1, str. 43-49, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:626644. [Citirano: 19.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:626644
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Podaci o radu
Naslov (engleski)Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
AutorAleksandra Šustar
AutorMatea Nikolac Perković
AutorGordana Nedić Erjavec
AutorDubravka Švob Štrac
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background & objectives: Brain-derived neurotrophic factor (BDNF) facilitates neuronal survival, differentiation and synaptic connectivity and affects neurotransmission throughout the brain. However, it has also a modulatory role in energy homeostasis, obesity and cardiovascular function. Obesity, high body mass index (BMI) and dyslipidaemia, among other factors, contribute to coronary heart disease (CHD) development. The exact role of BDNF in development of CHD is not well defined. This study was aimed to evaluate if plasma BDNF concentration was associated with CHD in ethnically homogeneous groups of patients and to correlate plasma BDNF levels with known risk factors for CHD. Methods: Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls. Results: Plasma BDNF concentration was significantly (P <0.01) reduced in patients with CHD compared to controls, and it was not influenced by gender, age, smoking or BDNF Val66Met polymorphism. It was considerably correlated with cholesterol (P=0.004), low-density lipoprotein (P=0.006), and diastolic blood pressure (P=0.018) in patients with CHD and with platelet number (P=0.003) in healthy controls. Interpretation & conclusions: The results revealed lower plasma BDNF concentration in patients with CHD, suggesting that decreased plasma BDNF concentration might be associated with CHD pathogenesis. Longitudinal studies with a large sample need to be conducted to confirm these findings.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaIndian Journal of Medical Research
Brojčani podacivol. 150, br. 1, str. 43-49
p-ISSN0971-5916
DOIhttps://doi.org/10.4103/ijmr.IJMR_1566_17
URN:NBNurn:nbn:hr:184:626644
Datum objave publikacije2019
ProjektŠifra: 098-0982522-2455
Naziv (hrvatski): Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja
Voditelj: Nela Pivac
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://www.ijmr.org.in/text.asp?2019/150/1/43/268213
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2020-04-17 16:29:19