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Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis
Neuroimmunomodulation, 20 (2013), 3; 152-163. https://doi.org/10.1159/000346546
Grubić Kezele, Tanja; Jakovac, Hrvoje; Tota, Marin; Čanadi Jurešić, Gordana; Barac-Latas, Vesna; Milin, Čedomila; Radošević-Stašić, Biserka

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Grubić Kezele, T., Jakovac, H., Tota, M., Čanadi Jurešić, G., Barac Latas, V., Milin, Č. i Radošević Stašić, B. (2013). Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis. Neuroimmunomodulation, 20. (3), 152-163. doi: 10.1159/000346546

Grubić Kezele, Tanja, et al. "Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis." Neuroimmunomodulation, vol. 20, br. 3, 2013, str. 152-163. https://doi.org/10.1159/000346546

Grubić Kezele, Tanja, Hrvoje Jakovac, Marin Tota, Gordana Čanadi Jurešić, Vesna Barac Latas, Čedomila Milin i Biserka Radošević Stašić. "Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis." Neuroimmunomodulation 20, br. 3 (2013): 152-163. https://doi.org/10.1159/000346546

Grubić Kezele, T., et al. (2013) 'Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis', Neuroimmunomodulation, 20(3), str. 152-163. doi: 10.1159/000346546

Grubić Kezele T, Jakovac H, Tota M, Čanadi Jurešić G, Barac Latas V, Milin Č, i sur.. Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis. Neuroimmunomodulation [Internet]. 2013. [pristupljeno 06.05.2024.];20(3):152-163. doi: 10.1159/000346546

T. Grubić Kezele, et al., "Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis", Neuroimmunomodulation, vol. 20, br. 3, str. 152-163, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:893650. [Citirano: 06.05.2024.]

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Naslov (engleski)Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis
AutorTanja Grubić Kezele
AutorHrvoje Jakovac
AutorMarin Tota
AutorGordana Čanadi Jurešić
AutorVesna Barac-Latas
AutorČedomila Milin
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Compared to the Dark Agouti (DA), the Albino Oxford (AO) rat strain exhibits lower susceptibility to the induction of experimental autoimmune encephalomyelitis (EAE). Here, we investigated the potential contribution of the heavy metal-binding proteins metallothioneins (MTs) I/II to these effects. Rats were immunized with bovine brain homogenate emulsified in complete Freund's adjuvant or only with complete Freund's adjuvant. The expression patterns of MTs mRNA and proteins and tissue concentrations of Zn2+ and Cu2+ were estimated in the brain and in the liver on days 7 and 12 after immunization, by real-time PCR, immunohistochemistry and inductively coupled plasma spectrometry, respectively. Additionally, the hepatic transforming growth factor beta and nuclear factor kappa B immunoreactivities were tested. Clinical signs of EAE were not induced in AO rats, but they upregulated the expression of MT I/II proteins in the brain (hippocampus and cerebellum) and in the liver, similarly as DA rats. The transcriptional activation of MT-I occurred, however, only in DA rats, which accumulated also more zinc in the brain and in the liver. In contrast, intact AO rats had greater hepatic MT-I mRNA immunoreactivity and more Cu2+ in the hippocampus. Besides, in immunized AO rats a high upregulation of transforming growth factor beta and nuclear factor kappa B immunoreactivities was found in several hepatic structures (vascular endothelium, Kupffer cells and hepatocytes). Our data show that AO and DA rats differ in constitutive and inductive MT-I gene expression in the brain and in the liver, as well as in the hepatic cytokine profile, suggesting that these mechanisms may contribute to the discrepancy in the susceptibility to EAE.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeuroimmunomodulation
Brojčani podacivol. 20, br. 3, str. 152-163
p-ISSN1021-7401
e-ISSN1021-7401
DOIhttps://doi.org/10.1159/000346546
URN:NBNurn:nbn:hr:184:893650
Datum objave publikacije2013
ProjektŠifra: 062-0621341-0061
Naziv (hrvatski): Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva.
Voditelj: Čedomila Milin
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621341-1337
Naziv (hrvatski): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Voditelj: Biserka Radošević-Stašić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/624329
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2020-04-08 09:35:26