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Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
eLife, 9 (2020); 50803. https://doi.org/10.7554/eLife.50803
Stražić Geljić, Ivana; Kučan Brlić, Paola; Angulo, Guillem; Brizić, Ilija; Lisnić, Berislav; Jenuš, Tina; Juranić Lisnić, Vanda; Pietri, Gian Pietro; Engel, Pablo; Kaynan, Noa; Železnjak, Jelena; Schu, Peter; Mandelboim, Ofer; Krmpotić, Astrid; Angulo, Ana; Jonjić, Stipan; Lenac Roviš, Tihana Više autora...

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Stražić Geljić, I., Kučan Brlić, P., Angulo, G., Brizić, I., Lisnić, B., Jenuš, T. ... Lenac Roviš, T. (2020). Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion. eLife, 9.. doi: 10.7554/eLife.50803

Stražić Geljić, Ivana, et al. "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion." eLife, vol. 9, 2020. https://doi.org/10.7554/eLife.50803

Stražić Geljić, Ivana, Paola Kučan Brlić, Guillem Angulo, Ilija Brizić, Berislav Lisnić, Tina Jenuš, Vanda Juranić Lisnić, et al. "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion." eLife 9 (2020). https://doi.org/10.7554/eLife.50803

Stražić Geljić, I., et al. (2020) 'Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion', eLife, 9. doi: 10.7554/eLife.50803

Stražić Geljić I, Kučan Brlić P, Angulo G, Brizić I, Lisnić B, Jenuš T, i sur.. Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion. eLife [Internet]. 13.01.2020. [pristupljeno 12.12.2024.];9. doi: 10.7554/eLife.50803

I. Stražić Geljić, et al., "Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion", eLife, vol. 9, Siječanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:461982. [Citirano: 12.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:461982
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Naslov (engleski)Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
AutorIvana Stražić Geljić
AutorPaola Kučan Brlić
AutorGuillem Angulo
AutorIlija Brizić
AutorBerislav Lisnić
AutorTina Jenuš
AutorVanda Juranić Lisnić
AutorGian Pietro Pietri
AutorPablo Engel
AutorNoa Kaynan
AutorJelena Železnjak
AutorPeter Schu
AutorOfer Mandelboim
AutorAstrid Krmpotić
AutorAna Angulo
AutorStipan Jonjić
AutorTihana Lenac Roviš
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activation and costimulation of the immune cells. We demonstrate that m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracellular protein sorting and packaging. As a consequence of the perturbed AP-1 sorting, m154 promotes lysosomal degradation of several proteins involved in T cell costimulation, thus impairing virus-specific CD8+ T cell response and virus control in vivo. Additionally, we show that HCMV infection similarly interferes with the AP-1 complex. Altogether, we identify the robust mechanism employed by single viral immunomodulatory protein targeting a broad spectrum of cell surface molecules involved in the antiviral immune response.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaeLife
Brojčani podacivol. 9, 50803
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.50803
URN:NBNurn:nbn:hr:184:461982
Datum objave publikacije2020-01-13
ProjektŠifra: UIP-2013-11-1533
Naziv (hrvatski): Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi
Kratica: PVRreg
Voditelj: Tihana Lenac Roviš
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://elifesciences.org/articles/50803
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-02-19 17:45:02