prikaz prve stranice dokumenta Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
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Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
Histology and Histopathology, 26 (2011), 2; 233-245. urn:nbn:hr:184:883327
Jakovac, Hrvoje; Grebić, Damir; Tota, Marin; Barac-Latas, Vesna; Mrakovčić-Šutić, Ines; Milin, Čedomila; Radošević-Stašić, Biserka

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Jakovac, H., Grebić, D., Tota, M., Barac Latas, V., Mrakovčić Šutić, I., Milin, Č. i Radošević Stašić, B. (2011). Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats. Histology and Histopathology, 26. (2), 233-245. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, Hrvoje, et al. "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats." Histology and Histopathology, vol. 26, br. 2, 2011, str. 233-245. https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, Hrvoje, Damir Grebić, Marin Tota, Vesna Barac Latas, Ines Mrakovčić Šutić, Čedomila Milin i Biserka Radošević Stašić. "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats." Histology and Histopathology 26, br. 2 (2011): 233-245. https://urn.nsk.hr/urn:nbn:hr:184:883327

Jakovac, H., et al. (2011) 'Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats', Histology and Histopathology, 26(2), str. 233-245. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:883327 (Datum pristupa: 19.11.2024.)

Jakovac H, Grebić D, Tota M, Barac Latas V, Mrakovčić Šutić I, Milin Č, i sur.. Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats. Histology and Histopathology [Internet]. 2011. [pristupljeno 19.11.2024.];26(2):233-245. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:883327

H. Jakovac, et al., "Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats", Histology and Histopathology, vol. 26, br. 2, str. 233-245, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:883327. [Citirano: 19.11.2024.]

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Naslov (engleski)Time-course expression of metallothioneins and tissue metals in chronic relapsing experimental autoimmune encephalomyelitis in DA rats
AutorHrvoje Jakovac
AutorDamir Grebić
AutorMarin Tota
AutorVesna Barac-Latas
AutorInes Mrakovčić-Šutić
AutorČedomila Milin
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
To elucidate the role of metallothioneins (MTs) in the pathomechanisms of autoimmune CNS disorders we estimated the expression of MTs I+II and the tissue concentrations of Zn2+ and Cu2+ in the brain, spinal cord (SC) and in the liver during the periods of attacks and remissions in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE). Disease was induced in the genetically susceptible Dark Agouti (DA) rats by subcutaneous injection of bovine brain homogenate in CFA. Control rats were treated with CFA or with saline solution. The data, obtained by clinical assessment, immunohistochemistry and inductivity coupled plasma spectrometry, have shown that during the first attack (12th day) MTs I+II were markedly upregulated in subarachnoid regions and perivascular space on astrocytes, microglia and spinal neurons. Simultaneously, increased the concentration of zinc in the SC and zinc and copper in the liver. During the second attack (22nd day) a new overexpression of MTs was found in the cerebellum, in sulcus hippocampi, in spinal neurons and particularly on hepatocytes around the central vein. Concomitantly, in the brain and SC increased the concentration of copper. The data point to neuroprotective role of MTs and to important regulatory role of essential metals and hepatic MTs in the pathogenesis of CR-EAE
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaHistology and Histopathology
Brojčani podacivol. 26, br. 2, str. 233-245
p-ISSN0213-3911
URN:NBNurn:nbn:hr:184:883327
Datum objave publikacije2011
ProjektŠifra: 062-0621341-1337
Naziv (hrvatski): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Voditelj: Biserka Radošević-Stašić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/442423
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2019-04-14 21:42:04