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Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1
PLoS ONE, 7 (2012), 5; e36837. https://doi.org/10.1371/journal.pone.0036837
Glasner, Ariella; Zurunić, Antonija; Meningher, Tal; Lenac Roviš, Tihana; Tsukerman, Pinchas; Bar-On, Yotam; Yamin, Rachel; Meyers, Adrienne F. A.; Mandeboim, Michal; Jonjić, Stipan; Mandelboim, Ofer

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Glasner, A., Zurunić, A., Meningher, T., Lenac Roviš, T., Tsukerman, P., Bar On, Y. ... Mandelboim, O. (2012). Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1. PLoS ONE, 7. (5). doi: 10.1371/journal.pone.0036837

Glasner, Ariella, et al. "Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1." PLoS ONE, vol. 7, br. 5, 2012. https://doi.org/10.1371/journal.pone.0036837

Glasner, Ariella, Antonija Zurunić, Tal Meningher, Tihana Lenac Roviš, Pinchas Tsukerman, Yotam Bar On, Rachel Yamin, et al. "Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1." PLoS ONE 7, br. 5 (2012). https://doi.org/10.1371/journal.pone.0036837

Glasner, A., et al. (2012) 'Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1', PLoS ONE, 7(5). doi: 10.1371/journal.pone.0036837

Glasner A, Zurunić A, Meningher T, Lenac Roviš T, Tsukerman P, Bar On Y, i sur.. Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1. PLoS ONE [Internet]. 15.05.2012. [pristupljeno 04.04.2025.];7(5). doi: 10.1371/journal.pone.0036837

A. Glasner, et al., "Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1", PLoS ONE, vol. 7, br. 5, Svibanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:515371. [Citirano: 04.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:515371
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Podaci o radu
Naslov (engleski)Elucidating the Mechanisms of Influenza Virus Recognition by Ncr1
AutorAriella Glasner
AutorAntonija Zurunić
AutorTal Meningher
AutorTihana Lenac Roviš
AutorPinchas Tsukerman
AutorYotam Bar-On
AutorRachel Yamin
AutorAdrienne F. A. Meyers
AutorMichal Mandeboim
AutorStipan Jonjić
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells are innate cytotoxic lymphocytes that specialize in the defense against viral infection and oncogenic transformation. Their action is tightly regulated by signals derived from inhibitory and activating receptors; the later include proteins such as the Natural Cytotoxicity Receptors (NCRs: NKp46, NKp44 and NKp30). Among the NCRs, NKp46 is the only receptor that has a mouse orthologue named Ncr1. NKp46/Ncr1 is also a unique marker expressed on NK and on Lymphoid tissue... Više inducer (LTI) cells and it was implicated in the control of various viral infections, cancer and diabetes. We have previously shown that human NKp46 recognizes viral hemagglutinin (HA) in a sialic acid-dependent manner and that the Oglycosylation is essential for the NKp46 binding to viral HA. Here we studied the molecular interactions between Ncr1 and influenza viruses. We show that Ncr1 recognizes influenza virus in a sialic acid dependent manner and that N-glycosylation is important for this binding. Surprisingly we demonstrate that none of the predicted N-glycosilated residues of Ncr1 are essential for its binding to influenza virus and we thus conclude that other, yet unidentified N-glycosilated residues are responsible for its recognition. We have demonstrated that N glycosylation play little role in the recognition of mouse tumor cell lines and also showed the in-vivo importance of Ncr1 in the control of influenza virus infection by infecting C57BL/6 and BALB/c mice knockout for Ncr1 with influenza. Sakrij dio sažetka
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 7, br. 5, e36837
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0036837
URN:NBNurn:nbn:hr:184:515371
Datum objave publikacije2012-05-15
URL dokumentahttp://dx.plos.org/10.1371/journal.pone.0036837
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-04-04 06:19:59
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