prikaz prve stranice dokumenta The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection
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The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection
The EMBO Journal, 38 (2019), 5; 100983. https://doi.org/10.15252/embj.2018100983
Stempel, Markus; Chan, Baca; Juranić Lisnić, Vanda; Krmpotić, Astrid; Hartung, Josephine; Paludan, Søren R; Füllbrunn, Nadia; Lemmermann, Niels AW; Brinkmann, Melanie M.

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Stempel, M., Chan, B., Juranić Lisnić, V., Krmpotić, A., Hartung, J., Paludan, S. R. ... Brinkmann, M. M. (2019). The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection. The EMBO Journal, 38. (5). doi: 10.15252/embj.2018100983

Stempel, Markus, et al. "The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection." The EMBO Journal, vol. 38, br. 5, 2019. https://doi.org/10.15252/embj.2018100983

Stempel, Markus, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R Paludan, Nadia Füllbrunn, Niels AW Lemmermann i Melanie M. Brinkmann. "The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection." The EMBO Journal 38, br. 5 (2019). https://doi.org/10.15252/embj.2018100983

Stempel, M., et al. (2019) 'The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection', The EMBO Journal, 38(5). doi: 10.15252/embj.2018100983

Stempel M, Chan B, Juranić Lisnić V, Krmpotić A, Hartung J, Paludan SR, i sur.. The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection. The EMBO Journal [Internet]. 29.01.2019. [pristupljeno 25.04.2024.];38(5). doi: 10.15252/embj.2018100983

M. Stempel, et al., "The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection", The EMBO Journal, vol. 38, br. 5, Siječanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:499363. [Citirano: 25.04.2024.]

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Naslov (engleski)The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection
AutorMarkus Stempel
AutorBaca Chan
AutorVanda Juranić Lisnić
AutorAstrid Krmpotić
AutorJosephine Hartung
AutorSøren R Paludan
AutorNadia Füllbrunn
AutorNiels AW Lemmermann
AutorMelanie M. Brinkmann
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegaloviruses (CMVs) are master manipulators of the host immune response. Here, we reveal that the murine CMV (MCMV) protein m152 specifically targets the type I interferon (IFN) response by binding to stimulator of interferon genes (STING), thereby delaying its trafficking to the Golgi compartment from where STING initiates type I IFN signaling. Infection with an MCMV lacking m152 induced elevated type I IFN responses and this leads to reduced viral transcript levels both in vitro and in vivo This effect is ameliorated in the absence of STING Interestingly, while m152 inhibits STING-mediated IRF signaling, it did not affect STING-mediated NF-κB signaling. Analysis of how m152 targets STING translocation reveals that STING activates NF-κB signaling already from the ER prior to its trafficking to the Golgi. Strikingly, this response is important to promote early MCMV replication. Our results show that MCMV has evolved a mechanism to specifically antagonize the STING-mediated antiviral IFN response, while preserving its pro-viral NF-κB response, providing an advantage in the establishment of an infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaThe EMBO Journal
Brojčani podacivol. 38, br. 5, 100983
p-ISSN0261-4189
e-ISSN1460-2075
DOIhttps://doi.org/10.15252/embj.2018100983
URN:NBNurn:nbn:hr:184:499363
Datum objave elektroničkog izdanja2019-01-29
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttp://emboj.embopress.org/lookup/doi/10.15252/embj.2018100983
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-02-01 10:12:27