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A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis
ImmunoHorizons, 1 (2017), 9; 198-212. https://doi.org/10.4049/immunohorizons.1700011
Trembath, Andrew P.; Sharma, Neekun; Raju, Saravanan; Polić, Bojan; Markiewicz, Mary A.

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Trembath, A. P., Sharma, N., Raju, S., Polić, B. i Markiewicz, M. A. (2017). A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis. ImmunoHorizons, 1. (9), 198-212. doi: 10.4049/immunohorizons.1700011

Trembath, Andrew P., et al. "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis." ImmunoHorizons, vol. 1, br. 9, 2017, str. 198-212. https://doi.org/10.4049/immunohorizons.1700011

Trembath, Andrew P., Neekun Sharma, Saravanan Raju, Bojan Polić i Mary A. Markiewicz. "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis." ImmunoHorizons 1, br. 9 (2017): 198-212. https://doi.org/10.4049/immunohorizons.1700011

Trembath, A. P., et al. (2017) 'A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis', ImmunoHorizons, 1(9), str. 198-212. doi: 10.4049/immunohorizons.1700011

Trembath AP, Sharma N, Raju S, Polić B, Markiewicz MA. A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis. ImmunoHorizons [Internet]. 07.11.2017. [pristupljeno 27.12.2024.];1(9):198-212. doi: 10.4049/immunohorizons.1700011

A. P. Trembath, N. Sharma, S. Raju, B. Polić i M. A. Markiewicz, "A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis", ImmunoHorizons, vol. 1, br. 9, str. 198-212, Studeni 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:810946. [Citirano: 27.12.2024.]

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Naslov (engleski)A Protective Role for NKG2D–H60a Interaction via Homotypic T Cell Contact in Nonobese Diabetic Autoimmune Diabetes Pathogenesis
AutorAndrew P. Trembath
AutorNeekun Sharma
AutorSaravanan Raju https://orcid.org/0000-0001-8904-8497
AutorBojan Polić
AutorMary A. Markiewicz https://orcid.org/0000-0001-5685-8573
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The NK group 2 member D (NKG2D) immune receptor is implicated in both human and mouse autoimmune diabetes. However, the significance of NKG2D in diabetes pathogenesis has been unclear due to conflicting reports as to the importance of this receptor in the NOD mouse model. In this study we demonstrate that NKG2D expression affects NOD diabetes development by at least two previously undescribed, and opposing, mechanisms. First, we demonstrate that the NKG2D ligand H60a is induced on activated NOD T cells, and that NKG2D–H60a interaction during CD8+ T cell differentiation into CTLs generally decreases the subsequent CTL effector cytokine response. This corresponds to an increase in diabetes development in NKG2D-deficient compared with wild-type NOD mice under microbiota-depleted conditions. Second, we demonstrate that NKG2D promotes NOD diabetes development through interaction with the microbiota. Together these findings reveal a previously undescribed role for NKG2D ligand expression by activated T cells in CTL development. Further, they demonstrate that NKG2D has both diabetogenic and antidiabetogenic roles in NOD diabetes development.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunoHorizons
Brojčani podacivol. 1, br. 9, str. 198-212
e-ISSN2573-7732
DOIhttps://doi.org/10.4049/immunohorizons.1700011
URN:NBNurn:nbn:hr:184:810946
Datum objave publikacije2017-11-07
Datum objave publikacije2017-11-01
URL dokumentahttp://www.immunohorizons.org/lookup/doi/10.4049/immunohorizons.1700011
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2018-11-30 07:21:48