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Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
Immunity, 40 (2014), 6; 961-973. https://doi.org/10.1016/j.immuni.2014.05.003
Crouse, Josh; Bedenikovic, Gregor; Wiesel, Melanie; Ibberson, Mark; Xenarios, Ioannis; Von Laer, Dorothee; Kalinke, Ulrich; Vivier, Eric; Jonjić, Stipan; Oxenius, Annette

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Crouse, J., Bedenikovic, G., Wiesel, M., Ibberson, M., Xenarios, I., Von Laer, D. ... Oxenius, A. (2014). Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity, 40. (6), 961-973. doi: 10.1016/j.immuni.2014.05.003

Crouse, Josh, et al. "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1." Immunity, vol. 40, br. 6, 2014, str. 961-973. https://doi.org/10.1016/j.immuni.2014.05.003

Crouse, Josh, Gregor Bedenikovic, Melanie Wiesel, Mark Ibberson, Ioannis Xenarios, Dorothee Von Laer, Ulrich Kalinke, Eric Vivier, Stipan Jonjić i Annette Oxenius. "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1." Immunity 40, br. 6 (2014): 961-973. https://doi.org/10.1016/j.immuni.2014.05.003

Crouse, J., et al. (2014) 'Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1', Immunity, 40(6), str. 961-973. doi: 10.1016/j.immuni.2014.05.003

Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, i sur.. Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity [Internet]. 06.2014. [pristupljeno 27.12.2024.];40(6):961-973. doi: 10.1016/j.immuni.2014.05.003

J. Crouse, et al., "Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1", Immunity, vol. 40, br. 6, str. 961-973, Lipanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:143323. [Citirano: 27.12.2024.]

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Naslov (engleski)Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
AutorJosh Crouse
AutorGregor Bedenikovic
AutorMelanie Wiesel
AutorMark Ibberson
AutorIoannis Xenarios
AutorDorothee Von Laer
AutorUlrich Kalinke
AutorEric Vivier
AutorStipan Jonjić
AutorAnnette Oxenius
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion, differentiation, and survival of responding T cells following infection with viruses prominently inducing type I IFN. The reasons for the abortive response of T cells lacking the type I IFN receptor (Ifnar1(-/-)) remain unclear. We report here that Ifnar1(-/-) T cells were highly susceptible to natural killer (NK) cell-mediated killing in a perforin-dependent manner. Depletion of NK cells prior to lymphocytic choriomeningitis virus (LCMV) infection completely restored the early expansion of Ifnar1(-/-) T cells. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunity
Brojčani podacivol. 40, br. 6, str. 961-973
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2014.05.003
URN:NBNurn:nbn:hr:184:143323
Datum objave publikacije2014-06
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 268537
Naziv (engleski): The Immune function of NK cells
Kratica: THINK
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1074761314001812
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-22 22:04:23