Introduction: ECMO is an extracorporeal cardiopulmonary support that provides an effective circulatory and respiratory support in heavily ill, life-threatening patients. The aim was to present the experiences and results of the use of ECMO support at UHC Rijeka. Patients and methods: The present thesis examined the history of diseases in patients treated with ECMO support in KBC Rijeka. Indications for ECMO support were based on physical, laboratory and ultrasound findings. Patients treated with VV ECMO support suffered from severe ARDS. VA ECMO support was used on patients suffering from cardiogenic shock, hemodynamically unstable patients and patients with unsatisfactory organ perfusion followed by a high dose of inotropic and vasopressor drugs. Results: We analyzed 82 patients who underwent ECMO. VA ECMO support was used on 70 patients, of whom 54 male patients underwent a median treatment duration of 3 days. VV ECMO support was utilized on 12 patients, of whom 9 were male and whose median treatment duration was 13 days. The survival rate of patients who underwent VA ECMO support was 63% while 67% of patients survived VV ECMO support. Most frequently occurring complication, seen in both types of ECMO support, was bleeding. Conclusion: The most common indication for initiation of the VA ECMO support was a cardiogenic shock, due to acute myocardial infarction while VV ECMO devices were used on patients who developed severe ARDS.