prikaz prve stranice dokumenta Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
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Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
Pathology Research International, 2014 (2014); 1-8. https://doi.org/10.1155/2014/262195
Oguić, Romano; Mozetič, Vladimir; Cini Tešar, Eleonora; Fučkar Čupić, Dora; Mustać, Elvira; Đorđević, Gordana

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Oguić, R., Mozetič, V., Cini Tešar, E., Fučkar Čupić, D., Mustać, E. i Đorđević, G. (2014). Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens. Pathology Research International, 2014., 1-8. doi: 10.1155/2014/262195

Oguić, Romano, et al. "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens." Pathology Research International, vol. 2014, 2014, str. 1-8. https://doi.org/10.1155/2014/262195

Oguić, Romano, Vladimir Mozetič, Eleonora Cini Tešar, Dora Fučkar Čupić, Elvira Mustać i Gordana Đorđević. "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens." Pathology Research International 2014 (2014): 1-8. https://doi.org/10.1155/2014/262195

Oguić, R., et al. (2014) 'Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens', Pathology Research International, 2014, str. 1-8. doi: 10.1155/2014/262195

Oguić R, Mozetič V, Cini Tešar E, Fučkar Čupić D, Mustać E, Đorđević G. Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens. Pathology Research International [Internet]. 06.07.2014. [pristupljeno 04.11.2024.];2014:1-8. doi: 10.1155/2014/262195

R. Oguić, V. Mozetič, E. Cini Tešar, D. Fučkar Čupić, E. Mustać i G. Đorđević, "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens", Pathology Research International, vol. 2014, str. 1-8, Srpanj 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:023922. [Citirano: 04.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:023922
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Podaci o radu
Naslov (engleski)Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
AutorRomano Oguić
AutorVladimir Mozetič
AutorEleonora Cini Tešar
AutorDora Fučkar Čupić
AutorElvira Mustać
AutorGordana Đorđević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za onkologiju i radioterapiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
The aim of this study was to evaluate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins . MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence . In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence . Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; ). Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass . The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathology Research International
Brojčani podacivol. 2014, str. 1-8
p-ISSN2090-8091
e-ISSN2042-003X
DOIhttps://doi.org/10.1155/2014/262195
URN:NBNurn:nbn:hr:184:023922
Datum objave publikacije2014-07-06
ProjektŠifra: 062-0620095-0077
Naziv (hrvatski): Molekularni mehanizmi tumorske progresije i metastaziranja raka dojke i prostate
Voditelj: Elvira Mustać
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://www.hindawi.com/archive/2014/262195/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-13 15:56:05