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Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State
Journal of Virology, 85 (2011), 19; 10286-10299. https://doi.org/10.1128/JVI.00373-11
Kropp, Kai A.; Robertson, Kevin A.; Sing, Garwin; Rodriguez-Martin, Sara; Blanc, Mathieu; Lacaze, Paul; Hassim, Muhamad F. B. Noor Hassim; Khondoker, Mizanur R.; Busche, Andreas; Dickinson, Paul; Forster, Thorsten; Strobl, Birgit; Mueller, Mathias; Jonjić, Stipan; Angulo, Ana; Ghazal, Peter Više autora...

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Kropp, K. A., Robertson, K. A., Sing, G., Rodriguez Martin, S., Blanc, M., Lacaze, P. ... Ghazal, P. (2011). Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State. Journal of Virology, 85. (19), 10286-10299. doi: 10.1128/JVI.00373-11

Kropp, Kai A., et al. "Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State." Journal of Virology, vol. 85, br. 19, 2011, str. 10286-10299. https://doi.org/10.1128/JVI.00373-11

Kropp, Kai A., Kevin A. Robertson, Garwin Sing, Sara Rodriguez Martin, Mathieu Blanc, Paul Lacaze, Muhamad F. B. Noor Hassim Hassim, et al. "Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State." Journal of Virology 85, br. 19 (2011): 10286-10299. https://doi.org/10.1128/JVI.00373-11

Kropp, K. A., et al. (2011) 'Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State', Journal of Virology, 85(19), str. 10286-10299. doi: 10.1128/JVI.00373-11

Kropp KA, Robertson KA, Sing G, Rodriguez Martin S, Blanc M, Lacaze P, i sur.. Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State. Journal of Virology [Internet]. 20.07.2011. [pristupljeno 26.04.2024.];85(19):10286-10299. doi: 10.1128/JVI.00373-11

K. A. Kropp, et al., "Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State", Journal of Virology, vol. 85, br. 19, str. 10286-10299, Srpanj 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:796831. [Citirano: 26.04.2024.]

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Naslov (engleski)Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State
AutorKai A. Kropp
AutorKevin A. Robertson
AutorGarwin Sing
AutorSara Rodriguez-Martin
AutorMathieu Blanc
AutorPaul Lacaze
AutorMuhamad F. B. Noor Hassim Hassim
AutorMizanur R. Khondoker
AutorAndreas Busche
AutorPaul Dickinson
AutorThorsten Forster
AutorBirgit Strobl
AutorMathias Mueller
AutorStipan Jonjić
AutorAna Angulo
AutorPeter Ghazal
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Activated macrophages play a central role in controlling inflammatory responses to infection and are tightly regulated to rapidly mount responses to infectious challenge. Type I interferon (alpha/beta interferon [IFN-α/β]) and type II interferon (IFN-γ) play a crucial role in activating macrophages and subsequently restricting viral infections. Both types of IFNs signal through related but distinct signaling pathways, inducing a vast number of interferon-stimulated genes that are overlapping but distinguishable. The exact mechanism by which IFNs, particularly IFN-γ, inhibit DNA viruses such as cytomegalovirus (CMV) is still not fully understood. Here, we investigate the antiviral state developed in macrophages upon reversible inhibition of murine CMV by IFN-γ. On the basis of molecular profiling of the reversible inhibition, we identify a significant contribution of a restricted type I IFN subnetwork linked with IFN-γ activation. Genetic knockout of the type I-signaling pathway, in the context of IFN-γ stimulation, revealed an essential requirement for a primed type I-signaling process in developing a full refractory state in macrophages. A minimal transient induction of IFN-β upon macrophage activation with IFN-γ is also detectable. In dose and kinetic viral replication inhibition experiments with IFN-γ, the establishment of an antiviral effect is demonstrated to occur within the first hours of infection. We show that the inhibitory mechanisms at these very early times involve a blockade of the viral major immediate-early promoter activity. Altogether our results show that a primed type I IFN subnetwork contributes to an immediate-early antiviral state induced by type II IFN activation of macrophages, with a potential further amplification loop contributed by transient induction of IFN-β.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Virology
Brojčani podacivol. 85, br. 19, str. 10286-10299
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.00373-11
URN:NBNurn:nbn:hr:184:796831
Datum objave publikacije2011-07-20
Datum objave publikacije2011-10-01
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://jvi.asm.org/cgi/doi/10.1128/JVI.00373-11
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-09 08:22:41