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NK cells link obesity-induced adipose stress to inflammation and insulin resistance
Nature Immunology, 16 (2015), 4; 376-385. https://doi.org/10.1038/ni.3120
Wensveen, Felix M; Jelenčić, Vedrana; Valentić, Sonja; Šestan, Marko; Wensveen, Tamara Turk; Theurich, Sebastian; Glasner, Ariella; Mendrila, Davor; Štimac, Davor; Wunderlich, F Thomas; Brüning, Jens C; Mandelboim, Ofer; Polić, Bojan

Citirajte ovaj rad

Wensveen, F. M., Jelenčić, V., Valentić, S., Šestan, M., Wensveen, T. T., Theurich, S. ... Polić, B. (2015). NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nature Immunology, 16. (4), 376-385. doi: 10.1038/ni.3120

Wensveen, Felix M, et al. "NK cells link obesity-induced adipose stress to inflammation and insulin resistance." Nature Immunology, vol. 16, br. 4, 2015, str. 376-385. https://doi.org/10.1038/ni.3120

Wensveen, Felix M, Vedrana Jelenčić, Sonja Valentić, Marko Šestan, Tamara Turk Wensveen, Sebastian Theurich, Ariella Glasner, et al. "NK cells link obesity-induced adipose stress to inflammation and insulin resistance." Nature Immunology 16, br. 4 (2015): 376-385. https://doi.org/10.1038/ni.3120

Wensveen, F. M., et al. (2015) 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance', Nature Immunology, 16(4), str. 376-385. doi: 10.1038/ni.3120

Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, i sur.. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nature Immunology [Internet]. 02.03.2015. [pristupljeno 24.04.2024.];16(4):376-385. doi: 10.1038/ni.3120

F. M. Wensveen, et al., "NK cells link obesity-induced adipose stress to inflammation and insulin resistance", Nature Immunology, vol. 16, br. 4, str. 376-385, Ožujak 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:907823. [Citirano: 24.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:907823
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Naslov (engleski)NK cells link obesity-induced adipose stress to inflammation and insulin resistance
AutorFelix M Wensveen
AutorVedrana Jelenčić
AutorSonja Valentić
AutorMarko Šestan
AutorTamara Turk Wensveen
AutorSebastian Theurich
AutorAriella Glasner
AutorDavor Mendrila
AutorDavor Štimac
AutorF Thomas Wunderlich
AutorJens C Brüning
AutorOfer Mandelboim
AutorBojan Polić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the accumulation of proinflammatory macrophages in adipose tissue, but the immunological signals that trigger their accumulation remain unknown. We found that a phenotypically distinct population of tissue-resident natural killer (NK) cells represented a crucial link between obesity-induced adipose stress and VAT inflammation. Obesity drove the upregulation of ligands of the NK cell-activating receptor NCR1 on adipocytes; this stimulated NK cell proliferation and interferon-gamma (IFN-gamma) production, which in turn triggered the differentiation of proinflammatory macrophages and promoted insulin resistance. Deficiency of NK cells, NCR1 or IFN-gamma prevented the accumulation of proinflammatory macrophages in VAT and greatly ameliorated insulin sensitivity. Thus NK cells are key regulators of macrophage polarization and insulin resistance in response to obesity-induced adipocyte stress.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Immunology
Brojčani podacivol. 16, br. 4, str. 376-385
p-ISSN1529-2908
e-ISSN1529-2916
DOIhttps://doi.org/10.1038/ni.3120
URN:NBNurn:nbn:hr:184:907823
Datum objave publikacije2015-03-02
Datum objave publikacije2015-04
URL dokumentahttp://www.nature.com/articles/ni.3120
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-11-05 10:57:56