The feeling of pain during the sting and the application of local anesthesia in pediatric dentistry is one of the most difficult problem, although this is the only way to eliminate pain. Pain is one of the main causes of fear and anxiety in children's dental medicine. Certainly a great challenge for the doctor of dental medicine is preparing and giving local anesthesia in children. It is necessary to have good knowledge in local anesthetics, their pharmacology and pharmacokinetics, the anatomy of the head and neck, and also required indications for use local anesthesia techniques.. Experience of anesthesia in a child pacient depends largely on the dental medicine therapist: a distraction, visualization, a slow and safe use of topical anesthetic and the introduction of new techniques without using injection needles. The dental therapist should try to avoid the invasive and painful procedure while administering local anesthesia, although today we know the injection is still the method of choice in providing painless dental treatment. In pediatric dentistry great importance is to find the right anesthetic for a specific indication. The safest on is Mepivakain which can be used without vasoconstrictors and is particularly usable for patients who suggest allergy to the vasoconstrictor in their anamnesis. With careful selection and knowing the properties of local anesthetic and administering a minimal dose with an effective effect and with well-chosen local anesthetic technique, we reduce the possibility of local and systemic complications.