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The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis
Collegium antropologicum, 34 supplement 1 (2010), 1; 267-271. urn:nbn:hr:184:930714
Barac-Latas, Vesna; Muhvić, Damir; Radošević-Stašić, Biserka

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Barac Latas, V., Muhvić, D. i Radošević Stašić, B. (2010). The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis. Collegium antropologicum, 34 supplement 1. (1), 267-271. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:930714

Barac Latas, Vesna, et al. "The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis." Collegium antropologicum, vol. 34 supplement 1, br. 1, 2010, str. 267-271. https://urn.nsk.hr/urn:nbn:hr:184:930714

Barac Latas, Vesna, Damir Muhvić i Biserka Radošević Stašić. "The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis." Collegium antropologicum 34 supplement 1, br. 1 (2010): 267-271. https://urn.nsk.hr/urn:nbn:hr:184:930714

Barac Latas, V., Muhvić, D. i Radošević Stašić, B. (2010) 'The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis', Collegium antropologicum, 34 supplement 1(1), str. 267-271. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:930714 (Datum pristupa: 19.11.2024.)

Barac Latas V, Muhvić D, Radošević Stašić B. The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis. Collegium antropologicum [Internet]. 25.03.2010. [pristupljeno 19.11.2024.];34 supplement 1(1):267-271. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:930714

V. Barac Latas, D. Muhvić i B. Radošević Stašić, "The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis", Collegium antropologicum, vol. 34 supplement 1, br. 1, str. 267-271, Ožujak 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:930714. [Citirano: 19.11.2024.]

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Naslov (engleski)The Influence of Pregnancy on Development and Course of Chronic Relapsing Experimental Autoimmune Encephalomyelitis in Rats: Implications for Multiple Sclerosis
AutorVesna Barac-Latas
AutorDamir Muhvić
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Multiple sclerosis is a chronic, autoimmune disease of the central nervous system, which mainly affects young women during a reproductive period of life. Since, its symptoms might be significantly affected by pregnancy, in this study we investigated the development and kinetics of disease in the model of chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), induced in genetically susceptible Dark Agouti (DA) strain of rats. They were sensitized with bovine brain white matter homogenate (BBH) in complete Freund’s adjuvant during the first, second or third week of pregnancy, and the disease scores were compared between treatment groups, and identically treated nongravid females. Additionally, the susceptibility to the induction of EAE was tested in offspring of mothers that during the pregnancy were sensitized with BBH. The data have shown that pregnancy does not block the induction of EAE, but that it significantly changes the course of diseases, depending on time of immunization. In rats sensitized during the first week of gestation the onset of the clinical signs was delayed, but after the delivery the intensity of disease significantly increased. Similar aggravation, with appearance of monophasic form of disease was observed in the group of rats sensitized during the third week of gestation. On the contrary, in rats sensitized during the second week of gestation the beneficial effects were observed, with later onset of attacks, and lower disease score. Furthermore, offspring of these rats after immunization with BBH developed a monophasic form of EAE of lower intensity, suggesting that some protective factors might be transferred across the placenta.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 34 supplement 1, br. 1, str. 267-271
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:930714
Datum objave publikacije2010-03-25
URL dokumentahttps://hrcak.srce.hr/51776
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-07-24 10:09:37