The Willis-Ebkom's disease is a common neurological-sensorimotor disorder, which is characterized by unpleasant feelings in the limbs and with an irresistible need to move them. It most commonly affects the legs, but it can be manifested in the hands or the body. The unpleasant feelings are described differently. The most commonly mentioned are: shaking, stinging, burning, numbness, stiffness, tingling and pain in some cases. It is estimated that 1 out of 10 people develop these symptoms in some period of their life. The prevalence increases with age. In most cases the symptoms occur after 40 years of age, but in one third of the cases it occurs in childhood as well. The symptoms occur twice as much more frequently in women than in man. Willis-Ebkom's disease is divided into two forms: the primary (idiopathic) and secondary. The causes are different and in most cases, they remain unidentified. It is considered that genetics, the dysfunction of the dopaminergic system and the abnormalities in the iron metabolism play a vital role in the onset of the disease. The diagnosis of the disease is based on a clinical picture and on a positive family amnesis. The Willis-Ebkom's disease is commonly a lifelong condition, which generally responds well to pharmacological therapy. Unfortunately, there is still no cure that could be used for every patient, but most patients with WED find the cure which suits them best. The most commonly used drugs are: dopamine agonists, antiepileptics, opioids and benzodiazepines. The choice for an appropriate therapy depends on a variety of factors, which include the severity of the disease, the patient's age, comorbidities (e.g. pain, depression, anxiety), side effects of drugs and the patient's preferences. The goal of the therapy is to reduce or eliminate symptoms of WED and to improve day-to-day functioning, sleeping and the quality of life.