prikaz prve stranice dokumenta EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
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EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
British Journal of Biomedical Science, 19 (2012), 40; 1-8. https://doi.org/10.1186/1423-0127-19-40
Đorđević, Gordana; Matušan-Ilijaš, Koviljka; Hadžisejdić, Ita; Maričić, Anton; Grahovac, Blaženka; Jonjić, Nives

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Đorđević, G., Matušan Ilijaš, K., Hadžisejdić, I., Maričić, A., Grahovac, B. i Jonjić, N. (2012). EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. British Journal of Biomedical Science, 19. (40), 1-8. doi: 10.1186/1423-0127-19-40

Đorđević, Gordana, et al. "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma." British Journal of Biomedical Science, vol. 19, br. 40, 2012, str. 1-8. https://doi.org/10.1186/1423-0127-19-40

Đorđević, Gordana, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac i Nives Jonjić. "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma." British Journal of Biomedical Science 19, br. 40 (2012): 1-8. https://doi.org/10.1186/1423-0127-19-40

Đorđević, G., et al. (2012) 'EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma', British Journal of Biomedical Science, 19(40), str. 1-8. doi: 10.1186/1423-0127-19-40

Đorđević G, Matušan Ilijaš K, Hadžisejdić I, Maričić A, Grahovac B, Jonjić N. EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. British Journal of Biomedical Science [Internet]. 2012. [pristupljeno 26.04.2024.];19(40):1-8. doi: 10.1186/1423-0127-19-40

G. Đorđević, K. Matušan Ilijaš, I. Hadžisejdić, A. Maričić, B. Grahovac i N. Jonjić, "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma", British Journal of Biomedical Science, vol. 19, br. 40, str. 1-8, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:222934. [Citirano: 26.04.2024.]

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Podaci o radu
Naslov (engleski)EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
AutorGordana Đorđević
AutorKoviljka Matušan-Ilijaš
AutorIta Hadžisejdić
AutorAnton Maričić
AutorBlaženka Grahovac
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic significance of EGFR expression in clear cell renal cell carcinoma (CCRCC). The present study was designed to analyze more objectively the protein EGFR expression in CCRCC and to compare its value with EGFR gene copy number changes and clinicopathologic characteristics including patient survival. The protein EGFR expression was analyzed immunohistochemically on 94 CCRCC, and gene copy number alterations of EGFR by FISH analysis on 41 CCRCC selected according to distinct membrane EGFR staining. Membrane EGFR expression in tumor cells was heterogeneous with respect to the proportion of positive cells and staining intensity. FISH analysis did not reveal EGFR gene amplification, while polysomy of chromosome 7 found in 41% was associated with higher EGFR membrane expression. Moreover, EGFR overexpression was associated with a higher nuclear grade, larger tumor size and shorter patient’s survival, while there was no connection with pathological stage. In conclusion, the protein expression of EGFR had an impact on prognosis in patients with CCRCC, while an increased copy number of chromosome 7 could be the possible reason for EGFR protein overexpression in the absence of gene amplification.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBritish Journal of Biomedical Science
Brojčani podacivol. 19, br. 40, str. 1-8
p-ISSN0967-4845
DOIhttps://doi.org/10.1186/1423-0127-19-40
URN:NBNurn:nbn:hr:184:222934
Datum objave publikacije2012
URL dokumentahttp://bib.irb.hr/497994
URL dokumentahttp://www.jbiomedsci.com/content/19/1/40
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-05-21 06:30:54