prikaz prve stranice dokumenta Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
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Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
Oncogene, 37 (2018), 18; 2351-2366. https://doi.org/10.1038/s41388-017-0121-z
Lindström, Mikael S.; Jurada, Deana; Bursać, Slađana; Oršolic, Ines; Bartek, Jiri; Volarević, Siniša

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Lindström, M. S., Jurada, D., Bursać, S., Oršolic, I., Bartek, J. i Volarević, S. (2018). Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Oncogene, 37. (18), 2351-2366. doi: 10.1038/s41388-017-0121-z

Lindström, Mikael S., et al. "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis." Oncogene, vol. 37, br. 18, 2018, str. 2351-2366. https://doi.org/10.1038/s41388-017-0121-z

Lindström, Mikael S., Deana Jurada, Slađana Bursać, Ines Oršolic, Jiri Bartek i Siniša Volarević. "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis." Oncogene 37, br. 18 (2018): 2351-2366. https://doi.org/10.1038/s41388-017-0121-z

Lindström, M. S., et al. (2018) 'Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis', Oncogene, 37(18), str. 2351-2366. doi: 10.1038/s41388-017-0121-z

Lindström MS, Jurada D, Bursać S, Oršolic I, Bartek J, Volarević S. Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Oncogene [Internet]. 12.02.2018. [pristupljeno 16.11.2024.];37(18):2351-2366. doi: 10.1038/s41388-017-0121-z

M. S. Lindström, D. Jurada, S. Bursać, I. Oršolic, J. Bartek i S. Volarević, "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis", Oncogene, vol. 37, br. 18, str. 2351-2366, Veljača 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:398492. [Citirano: 16.11.2024.]

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Naslov (engleski)Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
AutorMikael S. Lindström
AutorDeana Jurada
AutorSlađana Bursać
AutorInes Oršolic
AutorJiri Bartek
AutorSiniša Volarević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that are responsible for protein synthesis. A wealth of research over the past 20 years has clearly indicated that both quantitative and qualitative alterations in ribosome biogenesis can drive the malignant phenotype via dysregulation of protein synthesis. However, numerous recent proteomic, genomic, and functional studies have implicated the nucleolus in the regulation of processes that are unrelated to ribosome biogenesis, including DNA-damage response, maintenance of genome stability and its spatial organization, epigenetic regulation, cell-cycle control, stress responses, senescence, global gene expression, as well as assembly or maturation of various ribonucleoprotein particles. In this review, the focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin. We will also present the most recent insights into how malfunction of these cellular processes may be a central driving force of human malignancies, and propose a promising new therapeutic approach for the treatment of cancer.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOncogene
Brojčani podacivol. 37, br. 18, str. 2351-2366
p-ISSN0950-9232
e-ISSN1476-5594
DOIhttps://doi.org/10.1038/s41388-017-0121-z
URN:NBNurn:nbn:hr:184:398492
Datum objave publikacije2018-02-12
ProjektŠifra: IP-2016-06-2079
Naziv (hrvatski): Uloga heterozigotnosti gena za ribosomski protein S6 u zloćudnoj preoprazbi stanica
Kratica: ONCO-RIB
Voditelj: Siniša Volarević
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
URL dokumentahttp://www.nature.com/articles/s41388-017-0121-z
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-05-08 19:17:54