prikaz prve stranice dokumenta Ribosome biogenesis in cancer: new players and therapeutic avenues
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Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer, 18 (2018), 1; 51-63. https://doi.org/10.1038/nrc.2017.104
Pelletier, Joffrey; Thomas, George; Volarević, Siniša

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Pelletier, J., Thomas, G. i Volarević, S. (2018). Ribosome biogenesis in cancer: new players and therapeutic avenues. Nature Reviews Cancer, 18. (1), 51-63. doi: 10.1038/nrc.2017.104

Pelletier, Joffrey, et al. "Ribosome biogenesis in cancer: new players and therapeutic avenues." Nature Reviews Cancer, vol. 18, br. 1, 2018, str. 51-63. https://doi.org/10.1038/nrc.2017.104

Pelletier, Joffrey, George Thomas i Siniša Volarević. "Ribosome biogenesis in cancer: new players and therapeutic avenues." Nature Reviews Cancer 18, br. 1 (2018): 51-63. https://doi.org/10.1038/nrc.2017.104

Pelletier, J., Thomas, G. i Volarević, S. (2018) 'Ribosome biogenesis in cancer: new players and therapeutic avenues', Nature Reviews Cancer, 18(1), str. 51-63. doi: 10.1038/nrc.2017.104

Pelletier J, Thomas G, Volarević S. Ribosome biogenesis in cancer: new players and therapeutic avenues. Nature Reviews Cancer [Internet]. 01.2018. [pristupljeno 04.05.2024.];18(1):51-63. doi: 10.1038/nrc.2017.104

J. Pelletier, G. Thomas i S. Volarević, "Ribosome biogenesis in cancer: new players and therapeutic avenues", Nature Reviews Cancer, vol. 18, br. 1, str. 51-63, Siječanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:981273. [Citirano: 04.05.2024.]

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Naslov (engleski)Ribosome biogenesis in cancer: new players and therapeutic avenues
AutorJoffrey Pelletier
AutorGeorge Thomas
AutorSiniša Volarević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein synthesis in every living cell. Ribosome biogenesis is one of the most multifaceted and energy- demanding processes in biology, involving a large number of assembly and maturation factors, the functions of which are orchestrated by multiple cellular inputs, including mitogenic signals and nutrient availability. Although causal associations between inherited mutations affecting ribosome biogenesis and elevated cancer risk have been established over the past decade, mechanistic data have emerged suggesting a broader role for dysregulated ribosome biogenesis in the development and progression of most spontaneous cancers. In this Opinion article, we highlight the most recent findings that provide new insights into the molecular basis of ribosome biogenesis in cancer and offer our perspective on how these observations present opportunities for the design of new targeted cancer treatments.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Reviews Cancer
Brojčani podacivol. 18, br. 1, str. 51-63
p-ISSN1474-175X
DOIhttps://doi.org/10.1038/nrc.2017.104
URN:NBNurn:nbn:hr:184:981273
Datum objave publikacije2018-01
URL dokumentahttp://bib.irb.hr/914939
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-01-22 18:02:37