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Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
Frontiers in Immunology, 7 (2016); 133. https://doi.org/10.3389/fimmu.2016.00133
Arapović, Maja; Brizić, Ilija; Popović, Branka; Jurković, Slaven; Jordan, Stefan; Krmpotić, Astrid; Arapović, Jurica; Jonjić, Stipan

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Arapović, M., Brizić, I., Popović, B., Jurković, S., Jordan, S., Krmpotić, A. ... Jonjić, S. (2016). Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Frontiers in Immunology, 7.. doi: 10.3389/fimmu.2016.00133

Arapović, Maja, et al. "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection." Frontiers in Immunology, vol. 7, 2016. https://doi.org/10.3389/fimmu.2016.00133

Arapović, Maja, Ilija Brizić, Branka Popović, Slaven Jurković, Stefan Jordan, Astrid Krmpotić, Jurica Arapović i Stipan Jonjić. "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection." Frontiers in Immunology 7 (2016). https://doi.org/10.3389/fimmu.2016.00133

Arapović, M., et al. (2016) 'Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection', Frontiers in Immunology, 7. doi: 10.3389/fimmu.2016.00133

Arapović M, Brizić I, Popović B, Jurković S, Jordan S, Krmpotić A, i sur.. Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Frontiers in Immunology [Internet]. 2016. [pristupljeno 26.12.2024.];7. doi: 10.3389/fimmu.2016.00133

M. Arapović, et al., "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection", Frontiers in Immunology, vol. 7, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:039075. [Citirano: 26.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:039075
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Naslov (engleski)Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
AutorMaja Arapović
AutorIlija Brizić
AutorBranka Popović
AutorSlaven Jurković
AutorStefan Jordan
AutorAstrid Krmpotić
AutorJurica Arapović
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response. This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine secretion upon mouse cytomegalovirus (MCMV) infection. Here, we confirmed that stronger activation and maturation of NK cells in perforin-deficient mice correlates with higher MCMV load. To further characterize the immunoregulatory potential of perfo- rin, we compared the response of NK cells that express or do not express perforin using bone-marrow chimeras. Our results demonstrated that the enhanced proliferation and maturation of NK cells in MCMV-infected bone-marrow chimeras is an intrinsic property of perforin-deficient NK cells. Thus, in addition to confirming that NK-cell proliferation is virus load dependent, our data extend this notion demonstrating that perforin plays an intrinsic role as a feedback mechanism in the regulation of NK-cell proliferation during viral infections
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 7, 133
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2016.00133
URN:NBNurn:nbn:hr:184:039075
Datum objave publikacije2016
ProjektŠifra: IP-2013-11-7132
Naziv (hrvatski): Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa
Kratica: ViSpeNKRec
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://www.readcube.com/articles/10.3389/fimmu.2016.00133
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2018-01-18 15:25:32