prikaz prve stranice dokumenta Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor
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Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor
Medical Science Monitor, 19 (2013); 845-851. https://doi.org/10.12659/MSM.889554
Flego, Veljko; Ristić, Smiljana; Dević Pavlić, Sanja; Matanić Lender, Dubravka; Bulat-Kardum, Ljiljana; Radojčić Badovinac, Anđelka

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Flego, V., Ristić, S., Dević Pavlić, S., Matanić Lender, D., Bulat Kardum, Lj. i Radojčić Badovinac, A. (2013). Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor. Medical Science Monitor, 19., 845-851. doi: 10.12659/MSM.889554

Flego, Veljko, et al. "Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor." Medical Science Monitor, vol. 19, 2013, str. 845-851. https://doi.org/10.12659/MSM.889554

Flego, Veljko, Smiljana Ristić, Sanja Dević Pavlić, Dubravka Matanić Lender, Ljiljana Bulat Kardum i Anđelka Radojčić Badovinac. "Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor." Medical Science Monitor 19 (2013): 845-851. https://doi.org/10.12659/MSM.889554

Flego, V., et al. (2013) 'Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor', Medical Science Monitor, 19, str. 845-851. doi: 10.12659/MSM.889554

Flego V, Ristić S, Dević Pavlić S, Matanić Lender D, Bulat Kardum Lj, Radojčić Badovinac A. Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor. Medical Science Monitor [Internet]. 2013. [pristupljeno 16.04.2024.];19:845-851. doi: 10.12659/MSM.889554

V. Flego, S. Ristić, S. Dević Pavlić, D. Matanić Lender, Lj. Bulat Kardum i A. Radojčić Badovinac, "Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor", Medical Science Monitor, vol. 19, str. 845-851, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:614906. [Citirano: 16.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:614906
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Naslov (engleski)Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor
AutorVeljko Flego
AutorSmiljana Ristić
AutorSanja Dević Pavlić
AutorDubravka Matanić Lender
AutorLjiljana Bulat-Kardum
AutorAnđelka Radojčić Badovinac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Lung cancer is the most common second primary cancer. We investigated whether the TNF-a-308 and TNF-a-238 polymorphisms were associated with the susceptibility and severity of lung cancer as the second primary cancer (LC2). Material/Methods: This study included 104 patients from the group LC2. The control subjects included 2 groups. The first control group (LC1) comprised 201 unrelated patients with lung cancer as a first primary cancer. The second control group (HC) comprised 230 healthy blood donors, matched for sex and age to the study group. Results: The frequencies of the TNF-a-238 polymorphism GG genotype and the G allele were higher in the LC2 group than in the LC1 group, but the differences did not reach significance (p=0.054 and p=0.057, respectively). Similar differences were found in the TNF-a-238 polymorphism GG genotype and G allele between the LC2 group and the HC group (p=0.054 and p=0.057, respectively). In terms of the different types of lung cancer, patients with a second primary NSCLC (non-small cell lung cancer) more frequently had TNF-a-238 polymorphism GG genotypes and G alleles than patients with a first primary NSCLC (the differences approached statistical significance: p=0.060, p=0.064, respectively). All (100%) patients of group LC2 (n=104) had the GG genotype and the G allele. GG genotype was exclusive and no A allele was found in group LC2. Conclusions: TNF-a-238 polymorphism GG genotype and the G allele could have a promotional effect on the development of NSCLC in the group of patients with LC2.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 19, str. 845-851
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.889554
URN:NBNurn:nbn:hr:184:614906
Datum objave elektroničkog izdanja2013
URL dokumentahttps://www.medscimonit.com/download/index/idArt/889554
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-08-02 09:14:00