prikaz prve stranice dokumenta Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
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Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
Neurological Sciences, 37 (2016), 12; 1955-1959. https://doi.org/10.1007/s10072-016-2698-3
Ristić, Smiljana; Starčević-Čizmarević, Nada; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut

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Ristić, S., Starčević Čizmarević, N., Sepčić, J., Kapović, M. i Peterlin, B. (2016). Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis. Neurological Sciences, 37. (12), 1955-1959. doi: 10.1007/s10072-016-2698-3

Ristić, Smiljana, et al. "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis." Neurological Sciences, vol. 37, br. 12, 2016, str. 1955-1959. https://doi.org/10.1007/s10072-016-2698-3

Ristić, Smiljana, Nada Starčević Čizmarević, Juraj Sepčić, Miljenko Kapović i Borut Peterlin. "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis." Neurological Sciences 37, br. 12 (2016): 1955-1959. https://doi.org/10.1007/s10072-016-2698-3

Ristić, S., et al. (2016) 'Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis', Neurological Sciences, 37(12), str. 1955-1959. doi: 10.1007/s10072-016-2698-3

Ristić S, Starčević Čizmarević N, Sepčić J, Kapović M, Peterlin B. Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis. Neurological Sciences [Internet]. 27.08.2016. [pristupljeno 22.10.2024.];37(12):1955-1959. doi: 10.1007/s10072-016-2698-3

S. Ristić, N. Starčević Čizmarević, J. Sepčić, M. Kapović i B. Peterlin, "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis", Neurological Sciences, vol. 37, br. 12, str. 1955-1959, Kolovoz 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:838233. [Citirano: 22.10.2024.]

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Naslov (engleski)Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
AutorSmiljana Ristić
AutorNada Starčević-Čizmarević
AutorJuraj Sepčić
AutorMiljenko Kapović
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
The activity of angiotensin-converting enzyme (ACE) has been increased in the blood and cerebrospinal fluid of multiple sclerosis (MS) patients. In addition, there has been suppression of disease development in experimental autoimmune encephalomyelitis after blockade of ACE. These findings suggest that ACE may play a role in the MS pathogenesis. Since the previous studies investigating the association between the insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene and MS reported contradictory results, we performed a meta-analysis of four studies conducted in European populations of Slavic origin (1062 patients and 1067 controls) using the Comprehensive Meta-analysis 3.0 software. The results demonstrated that the ACE I/D polymorphism had no statistically significant association with an increased MS risk (all p aeyen 0.05) under all genetic comparison models: (1) allelic (D vs. I), (2) recessive (DD vs. ID + II), (3) dominant (DD + ID vs. II), and (4) additive (DD vs. ID vs. II). This meta-analysis indicates that the ACE I/D polymorphism is not associated with susceptibility to MS in Europeans of Slavic origin. Further studies with larger sample sizes from genetically different populations are warranted.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeurological Sciences
Brojčani podacivol. 37, br. 12, str. 1955-1959
p-ISSN1590-1874
e-ISSN1590-3478
DOIhttps://doi.org/10.1007/s10072-016-2698-3
URN:NBNurn:nbn:hr:184:838233
Datum objave elektroničkog izdanja2016-08-27
URL dokumentahttps://link.springer.com/article/10.1007/s10072-016-2698-3
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-08-01 10:07:31