prikaz prve stranice dokumenta Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
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Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
JOURNAL OF EXPERIMENTAL MEDICINE, 213 (2016), 9; 1835-1850. https://doi.org/10.1084/jem.20151899
Lenac Roviš, Tihana; Kučan Brlić, Paola; Kaynan, Noa; Juranić Lisnić, Vanda; Brizić, Ilija; Jordan, Stefan; Tomić, Adriana; Kveštak, Daria; Babić, Marina; Tsukerman, Pinchas; Colonna, Marco; Koszinowski, Ulrich; Messerle, Martin; Mandelboim, Ofer; Krmpotić, Astrid; Jonjić, Stipan Više autora...

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Lenac Roviš, T., Kučan Brlić, P., Kaynan, N., Juranić Lisnić, V., Brizić, I., Jordan, S. ... Jonjić, S. (2016). Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. JOURNAL OF EXPERIMENTAL MEDICINE, 213. (9), 1835-1850. doi: 10.1084/jem.20151899

Lenac Roviš, Tihana, et al. "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection." JOURNAL OF EXPERIMENTAL MEDICINE, vol. 213, br. 9, 2016, str. 1835-1850. https://doi.org/10.1084/jem.20151899

Lenac Roviš, Tihana, Paola Kučan Brlić, Noa Kaynan, Vanda Juranić Lisnić, Ilija Brizić, Stefan Jordan, Adriana Tomić, et al. "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection." JOURNAL OF EXPERIMENTAL MEDICINE 213, br. 9 (2016): 1835-1850. https://doi.org/10.1084/jem.20151899

Lenac Roviš, T., et al. (2016) 'Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection', JOURNAL OF EXPERIMENTAL MEDICINE, 213(9), str. 1835-1850. doi: 10.1084/jem.20151899

Lenac Roviš T, Kučan Brlić P, Kaynan N, Juranić Lisnić V, Brizić I, Jordan S, i sur.. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. JOURNAL OF EXPERIMENTAL MEDICINE [Internet]. 2016. [pristupljeno 07.05.2024.];213(9):1835-1850. doi: 10.1084/jem.20151899

T. Lenac Roviš, et al., "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 213, br. 9, str. 1835-1850, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:074639. [Citirano: 07.05.2024.]

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Naslov (engleski)Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
AutorTihana Lenac Roviš
AutorPaola Kučan Brlić
AutorNoa Kaynan
AutorVanda Juranić Lisnić
AutorIlija Brizić
AutorStefan Jordan
AutorAdriana Tomić
AutorDaria Kveštak
AutorMarina Babić
AutorPinchas Tsukerman
AutorMarco Colonna
AutorUlrich Koszinowski
AutorMartin Messerle
AutorOfer Mandelboim
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The poliovirus receptor (PVR) is a ubiquitously expressed glycoprotein involved in cellular adhesion and immune response. It engages the activating receptor DNAX accessory molecule (DNAM)-1, the inhibitory receptor TIG IT, and the CD96 receptor with both activating and inhibitory functions. Human cytomegalovirus (HCMV) down-regulates PVR expression, but the significance of this viral function in vivo remains unknown. Here, we demonstrate that mouse CMV (MCMV) also down-regulates the surface PVR. The m20.1 protein of MCMV retains PVR in the endoplasmic reticulum and promotes its degradation. A MCMV mutant lacking the PVR inhibitor was attenuated in normal mice but not in mice lacking DNAM-1. This attenuation was partially reversed by NK cell depletion, whereas the simultaneous depletion of mononuclear phagocytes abolished the virus control. This effect was associated with the increased expression of DNAM-1, whereas TIG IT and CD96 were absent on these cells. An increased level of proinflammatory cytokines in sera of mice infected with the virus lacking the m20.1 and an increased production of iNOS by inflammatory monocytes was observed. Blocking of CCL2 or the inhibition of iNOS significantly increased titer of the virus lacking m20.1. In this study, we have demonstrated that inflammatory monocytes, together with NK cells, are essential in the early control of CMV through the DNAM-1–PVR pathway
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJOURNAL OF EXPERIMENTAL MEDICINE
Brojčani podacivol. 213, br. 9, str. 1835-1850
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20151899
URN:NBNurn:nbn:hr:184:074639
Datum objave publikacije2016
ProjektŠifra: UIP-2013-11-1533
Naziv (hrvatski): Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi
Kratica: PVRreg
Voditelj: Tihana Lenac Roviš
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://jem.rupress.org/content/jem/213/9/1835.full.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 3.0 (CC BY-NC-ND 3.0)
Datum i vrijeme pohrane2017-12-27 10:04:28