prikaz prve stranice dokumenta Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
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Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
Biomarkers, 22 (2017), 8; 790-797. https://doi.org/10.1080/1354750X.2017.1351001
Bonifačić, David; Aralica, Merica; Sotošek Tokmadžić, Vlatka; Rački, Valentino; Tuškan-Mohar, Lidija; Kučić, Natalia

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Bonifačić, D., Aralica, M., Sotošek Tokmadžić, V., Rački, V., Tuškan Mohar, L. i Kučić, N. (2017). Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients. Biomarkers, 22. (8), 790-797. doi: 10.1080/1354750X.2017.1351001

Bonifačić, David, et al. "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients." Biomarkers, vol. 22, br. 8, 2017, str. 790-797. https://doi.org/10.1080/1354750X.2017.1351001

Bonifačić, David, Merica Aralica, Vlatka Sotošek Tokmadžić, Valentino Rački, Lidija Tuškan Mohar i Natalia Kučić. "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients." Biomarkers 22, br. 8 (2017): 790-797. https://doi.org/10.1080/1354750X.2017.1351001

Bonifačić, D., et al. (2017) 'Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients', Biomarkers, 22(8), str. 790-797. doi: 10.1080/1354750X.2017.1351001

Bonifačić D, Aralica M, Sotošek Tokmadžić V, Rački V, Tuškan Mohar L, Kučić N. Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients. Biomarkers [Internet]. 29.06.2017. [pristupljeno 04.05.2024.];22(8):790-797. doi: 10.1080/1354750X.2017.1351001

D. Bonifačić, M. Aralica, V. Sotošek Tokmadžić, V. Rački, L. Tuškan Mohar i N. Kučić, "Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients", Biomarkers, vol. 22, br. 8, str. 790-797, Lipanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:959430. [Citirano: 04.05.2024.]

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Naslov (engleski)Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients
AutorDavid Bonifačić
AutorMerica Aralica
AutorVlatka Sotošek Tokmadžić
AutorValentino Rački
AutorLidija Tuškan-Mohar
AutorNatalia Kučić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za neurologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Background: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to the outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Aim of our study was to determine whether these compounds can be used as potential prognostic biomarkers in ischaemic stroke, as a unique insight into the activity of the sympathetic nervous system. Methods: Urine samples of 96 patients with ischaemic stroke and transitory ischaemic attacks were analysed. Values of vanillylmandelic and homovanillic acids in urine were tested using liquid chromatography on the first and third day post-stroke. Severity of stroke was determined using the NIHSS scale, while functional outcome was determined using the Modified Rankin Scale. Results: Values of vanillylmandelic and homovanillic acids positively correlated with functional outcome of ischaemic stroke. Favorable outcomes correlated with decreased values, on contrary to increased values, which were associated with unfavourable outcomes. Conclusion: Determining the values of these compounds in the urine is an easily available prognostic tool for the ischaemic stroke outcome, while also influencing potential therapeutic changes
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomarkers
Brojčani podacivol. 22, br. 8, str. 790-797
p-ISSN1354-750X
e-ISSN1366-5804
DOIhttps://doi.org/10.1080/1354750X.2017.1351001
URN:NBNurn:nbn:hr:184:959430
Datum objave publikacije2017-06-29
URL dokumentahttps://doi.org/10.1080/1354750X.2017.1351001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-11-21 18:50:35