prikaz prve stranice dokumenta IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
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IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
PLoS Pathogens, 13 (2017), 4; e1006345. https://doi.org/10.1371/journal.ppat.1006345
Popović, Branka; Golemac, Mijo; Podlech, J.; Železnjak, Jelena; Bilić-Zulle, Lidija; Lukić, M.L.; Čičin-Šain, Luka; Reddehase, M.J.; Sparwasser, T.; Krmpotić, Astrid; Jonjić, Stipan

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Popović, B., Golemac, M., Podlech, J., Železnjak, J., Bilić Zulle, L., Lukić, M. ... Jonjić, S. (2017). IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.. PLoS Pathogens, 13. (4). doi: 10.1371/journal.ppat.1006345

Popović, Branka, et al. "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.." PLoS Pathogens, vol. 13, br. 4, 2017. https://doi.org/10.1371/journal.ppat.1006345

Popović, Branka, Mijo Golemac, J. Podlech, Jelena Železnjak, Lidija Bilić Zulle, M.L. Lukić, Luka Čičin Šain, et al. "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.." PLoS Pathogens 13, br. 4 (2017). https://doi.org/10.1371/journal.ppat.1006345

Popović, B., et al. (2017) 'IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.', PLoS Pathogens, 13(4). doi: 10.1371/journal.ppat.1006345

Popović B, Golemac M, Podlech J, Železnjak J, Bilić Zulle L, Lukić M, i sur.. IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.. PLoS Pathogens [Internet]. 27.04.2017. [pristupljeno 13.05.2024.];13(4). doi: 10.1371/journal.ppat.1006345

B. Popović, et al., "IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.", PLoS Pathogens, vol. 13, br. 4, Travanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:239373. [Citirano: 13.05.2024.]

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Naslov (engleski)IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
AutorBranka Popović
AutorMijo Golemac
AutorJ. Podlech
AutorJelena Železnjak
AutorLidija Bilić-Zulle
AutorM.L. Lukić
AutorLuka Čičin-Šain
AutorM.J. Reddehase
AutorT. Sparwasser
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Treg cells are crucial for immune homeostasis and for dampening immune response to several diseased conditions, including viral infections. Murine cytomegalovirus (MCMV) is a herpesvirus with pathogenic potential, so that early immune mechanisms are essential in controlling virus and protecting from virus-induced pathology. Studies on Foxp3+ Treg cells have revealed their inhibitory role on the early T cell response to MCMV infection and have suggested Treg cells as a target of MCMV’s immunoevasion mechanisms. Here we demonstrate that the number and activation status of liver Treg cells is strongly induced upon MCMV infection in order to protect the host from severe liver damage. They constitutively express high amounts of IL-33 receptor ST2 and their accumulation depends on IL-33, which is released as a tissue alarmin after the cell damage. For the first time, we show an immunoregulatory role of IL-33-dependent Treg cells in the liver of MCMV infected mice and their suppression of MCMV-induced immunopathology.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Pathogens
Brojčani podacivol. 13, br. 4, e1006345
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006345
URN:NBNurn:nbn:hr:184:239373
Datum objave publikacije2017-04-27
ProjektŠifra: 322693
Naziv (engleski): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Kratica: STADVINN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttps://doi.org/10.1371/journal.ppat.1006345
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2017-06-20 11:45:11