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Professional paper - Review paper
Laboratorijska dijagnostika bolesti jetre
Medicina Fluminensis : Medicina Fluminensis, 47 (2011), 3; 246-259. urn:nbn:hr:184:320248
Balen, Sanja; Dvornik, Štefica

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Balen, S. & Dvornik, Š. (2011). Laboratorijska dijagnostika bolesti jetre. Medicina Fluminensis : Medicina Fluminensis, 47. (3), 246-259. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:320248

Balen, Sanja and Štefica Dvornik. "Laboratorijska dijagnostika bolesti jetre." Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, 2011, pp. 246-259. https://urn.nsk.hr/urn:nbn:hr:184:320248

Balen, Sanja and Štefica Dvornik. "Laboratorijska dijagnostika bolesti jetre." Medicina Fluminensis : Medicina Fluminensis 47, no. 3 (2011): 246-259. https://urn.nsk.hr/urn:nbn:hr:184:320248

Balen, S. and Dvornik, Š. (2011) 'Laboratorijska dijagnostika bolesti jetre', Medicina Fluminensis : Medicina Fluminensis, 47(3), pp. 246-259. Available at: https://urn.nsk.hr/urn:nbn:hr:184:320248 (Accessed 05 May 2024)

Balen S, Dvornik Š. Laboratorijska dijagnostika bolesti jetre. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2011 September 05 [cited 2024 May 05];47(3):246-259. Available at: https://urn.nsk.hr/urn:nbn:hr:184:320248

S. Balen and Š. Dvornik, "Laboratorijska dijagnostika bolesti jetre", Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, pp. 246-259, September 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:320248. [Accessed: 05 May 2024]

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Metadata
Title (croatian)Laboratorijska dijagnostika bolesti jetre
Title (english)Laboratory diagnosis of liver disease
AuthorSanja Balen
AuthorŠtefica Dvornik
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Laboratorijska dijagnostika jetrenih bolesti može se s obzirom na pretrage podijeliti u tri skupine. To su laboratorijske pretrage koje ukazuju na oštećenje jetrenih stanica i funkciju jetre, laboratorijske pretrage kojima se može utvrditi uzrok bolesti, te funkcijski dinamički testovi kojima se procjenjuje sposobnost jetre da oslobodi organizam od štetnih tvari. U laboratorijskoj dijagnostici bolesti jetre, različite preporuke obično uključuju sljedeće početne testove probira: određivanje katalitičke aktivnosti enzima alanin aminotransferaze (ALT), aspartat aminotransferaze (AST) i alkalne fosfataze (ALP) u serumu, određivanje koncentracije bilirubina, te eventualno određivanje koncentracije ukupnih proteina i albumina u serumu. Ovisno o dobivenim rezultatima, spektar pretraga proširuje se kako bi se postavila dijagnoza. Osim za postavljanje dijagnoze, laboratorijske pretrage koriste se za prognozu i praćenje kliničkog stanja kod bolesnika s bolešću jetre�������������������������������������������������������������������������������������������. Oštećenje jetrenih stanica najčešće se dokazuje određivanjem aktivnosti AST i ALT u serumu, dok aktivnosti ALP i gama glutamil transferaze (GGT) ukazuju na poremećaj u kolestazi. S obzirom na to da je jetra glavno mjesto sinteze i uklanjanja čimbenika koagulacije i fibrinolize te njihovih inhibitora, oštećenje jetre uglavnom rezultira složenim poremećajima hemostaze. Koagulacijski poremećaji ovise o stupnju oštećenja jetrenog parenhima. U akutnom hepatitisu obično je prisutno umjereno sniženje F VII i vitamin K ovisnih faktora, što rezultira blagim produženjem protrombinskog vremena, a fibrinogen i F VIII mogu biti blago povišeni. U cirozi jetre stupanj hemostatskih poremećaja ovisan je o oštećenju jetrenih stanica i dobar je pokazatelj funkcije jetre. Laboratorijske pretrage kojima se može utvrditi uzrok bolesti su virusni biljezi, tumorski biljezi, autoantitijela, specifični proteini i mikroelementi.
Abstract (english)
There are three groups of tests for laboratory diagnostic of liver disease. The first group comprises laboratory tests which indicate damage of liver cells and liver function. The second group consists of tests which can determine the cause of liver disease, and the third group comprises functional dynamic tests which show the ability of liver to release harmful metabolic products from the body. Typical recommendations for laboratory diagnostics of liver disease include initial screening tests (enzyme activity of alanine aminotransferase (ALT), aspartat aminotransferase (AST) and alkaline phosphatase (ALP) in serum, concentration of bilirubin and eventually total protein and albumine concentrations), after which depending on obtained results, the physician can expand the diagnostics and perform other laboratory tests. Laboratory tests can help not only in establishing a diagnosis, but also in clinical prognoses and monitoring the course of liver disease. Activities of ALT and AST in serum indicate the damage of liver cells, while activities of ALP and gama-glutamyl transferase (GGT) indicate disorders in cholestasis. Liver is the main organ where coagulation and fibrinolysis factors and their inhibitors are synthesized, this liver damage will affect haemostasis. Coagulation disorders depend on the degree of the damage of liver parenchyma. In acute hepatitis there is usually moderate decrease of F VII and vitamin K dependent factors, resulting in a slight prolongation of prothrombin time, while fibrinogen and factor VIII can be elevated. In liver cirrhosis the degree of haemostatic disorders depends on the damage of liver cells and is a good indicator of liver function. Laboratory tests which can determine the cause of liver disease are: viral markers, tumor markers, auto antibodies, specific proteins and micronutrients.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 47, no. 3, pp. 246-259
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:320248
Publication2011-09-05
Document URLhttp://hrcak.srce.hr/71751
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-10 09:51:00