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Professional paper - Review paper
Terapijski pristup osteoporozi
Medicina Fluminensis : Medicina Fluminensis, 47 (2011), 3; 233-245. urn:nbn:hr:184:771258
Klobučar Majanović, Sanja; Crnčević Orlić, Željka; Jurišić Eržen, Dubravka; Vlahović-Palčevski, Vera; Štimac, Davor

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Klobučar Majanović, S., Crnčević Orlić, Ž., Jurišić Eržen, D., Vlahović Palčevski, V. & Štimac, D. (2011). Terapijski pristup osteoporozi. Medicina Fluminensis : Medicina Fluminensis, 47. (3), 233-245. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:771258

Klobučar Majanović, Sanja, et al. "Terapijski pristup osteoporozi." Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, 2011, pp. 233-245. https://urn.nsk.hr/urn:nbn:hr:184:771258

Klobučar Majanović, Sanja, Željka Crnčević Orlić, Dubravka Jurišić Eržen, Vera Vlahović Palčevski and Davor Štimac. "Terapijski pristup osteoporozi." Medicina Fluminensis : Medicina Fluminensis 47, no. 3 (2011): 233-245. https://urn.nsk.hr/urn:nbn:hr:184:771258

Klobučar Majanović, S., et al. (2011) 'Terapijski pristup osteoporozi', Medicina Fluminensis : Medicina Fluminensis, 47(3), pp. 233-245. Available at: https://urn.nsk.hr/urn:nbn:hr:184:771258 (Accessed 12 November 2024)

Klobučar Majanović S, Crnčević Orlić Ž, Jurišić Eržen D, Vlahović Palčevski V, Štimac D. Terapijski pristup osteoporozi. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2011 September 05 [cited 2024 November 12];47(3):233-245. Available at: https://urn.nsk.hr/urn:nbn:hr:184:771258

S. Klobučar Majanović, Ž. Crnčević Orlić, D. Jurišić Eržen, V. Vlahović Palčevski and D. Štimac, "Terapijski pristup osteoporozi", Medicina Fluminensis : Medicina Fluminensis, vol. 47, no. 3, pp. 233-245, September 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:771258. [Accessed: 12 November 2024]

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Metadata
Title (croatian)Terapijski pristup osteoporozi
Title (english)Therapeutic approach to osteoporosis
AuthorSanja Klobučar Majanović
AuthorŽeljka Crnčević Orlić
AuthorDubravka Jurišić Eržen
AuthorVera Vlahović-Palčevski
AuthorDavor Štimac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Osteoporoza je metabolička bolest kosti karakterizirana gubitkom koštane mase i poremećenom mikroarhitekturom koštanog tkiva, što za posljedicu ima povećanu krhkost kostiju i povećan rizik za nastanak prijeloma. Osnovni mehanizam nastanka osteoporoze je gubitak ravnoteže između koštane razgradnje i stvaranja nove kosti. Dijagnostički kriterij za osteoporozu je smanjena mineralna gustoća kosti za 2,5 standardne devijacije u odnosu na vršnu gustoću kosti (zdrave 30-godišnjakinje), utvrđeno denzitometrijom. Iako preventivne mjere, kao što su primjena kalcija, vitamina D, tjelovježba i reduciranje čimbenika rizika, trebaju biti sastavni dio pristupa bolesniku s osteoporozom, kako bi se postigla primjerena zaštita od prijeloma, u većine bolesnika potrebno je primijeniti i farmakološku terapiju. Nekoliko je lijekova dostupno za terapiju osteoporoze. Prema osnovnom mehanizmu djelovanja na kost klasificiraju se kao antiresorptivni ili osteoanabolički lijekovi. Antiresorptivni lijekovi u prvom redu smanjuju koštanu resorpciju, dok anabolici potiču stvaranje nove kosti. Ovaj članak donosi pregled lijekova koji se trenutno primjenjuju u liječenju osteoporoze, kao i budućih terapijskih opcija.
Abstract (english)
Osteoporosis is a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. The underlying mechanism in all cases of osteoporosis is an imbalance between bone resorption and bone formation. Osteoporosis is defined as a bone mineral density 2.5 standard deviations below peak bone mass (30-year old healthy female average) as measured by dual-emission X-ray absorptiometry. While preventive strategies, such as calcium, vitamin D, exercise and reduced risk factors should always be implemented, many patients will become candidates for pharmacologic intervention to achieve adequate fracture protection. There are several medications used to treat osteoporosis. According to primary effect on bone metabolism medications can be classified as antiresorptive or bone anabolic agents. Antiresorptive agents primarily reduce bone resorption, while anabolic agents induce bone formation. This article summarises the medications currently used in osteoporosis treatment, as well as future treatment options.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 47, no. 3, pp. 233-245
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:771258
Publication2011-09-05
Document URLhttp://hrcak.srce.hr/71750
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-10 09:44:00