Cartilage tissue is a special kind of supporting tissue due to optimal biomechanical properties, which are the result of specific biochemical structure of the intercellular matrix. Three types of cartilage – hyaline, fibrous and elastic – differ in the structure of the intercellular matrix and therefore in the physical properties. Arch-like distributed collagen fibers in all layers, significantly contribute to the elasticity and strength of articular cartilage, or possibilities for considerable reversible mechanical strain. The cartilage is avascular and without sensitive innervations. Nourishment of the articular cartilage and consequently its vitality depend directly on the activities of biomechanical forces, which ensure the diffusion of nutrients into the cartilage from the synovial fluid. Because of the latter fact in the initial stages of cartilage degeneration, symptoms of inflammation and pain are absent. With progression of degenerative changes, daily biomechanical load on the critically thinned cartilage leads to its disappearance, which ultimately results in joint dysfunction as in osteoarthritis.