prikaz prve stranice dokumenta Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases
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Scientific paper - Review paper
Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases
Gastrointestinal Disorders, 7 (2025), 2; 28. https://doi.org/10.3390/gidisord7020028
Jagodić, Ana; Kršek, Antea; Schleicher, Lou Marie Salomé; Batičić, Lara

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Jagodić, A., Kršek, A., Schleicher, L. M. S. & Batičić, L. (2025). Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases. Gastrointestinal Disorders, 7. (2). doi: 10.3390/gidisord7020028

Jagodić, Ana, et al. "Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases." Gastrointestinal Disorders, vol. 7, no. 2, 2025. https://doi.org/10.3390/gidisord7020028

Jagodić, Ana, Antea Kršek, Lou Marie Salomé Schleicher and Lara Batičić. "Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases." Gastrointestinal Disorders 7, no. 2 (2025). https://doi.org/10.3390/gidisord7020028

Jagodić, A., et al. (2025) 'Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases', Gastrointestinal Disorders, 7(2). doi: 10.3390/gidisord7020028

Jagodić A, Kršek A, Schleicher LMS, Batičić L. Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases. Gastrointestinal Disorders [Internet]. 2025 April 02 [cited 2025 April 08];7(2). doi: 10.3390/gidisord7020028

A. Jagodić, A. Kršek, L. M. S. Schleicher and L. Batičić, "Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases", Gastrointestinal Disorders, vol. 7, no. 2, April 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:950134. [Accessed: 08 April 2025]

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Metadata
Title (english)Microbiome Dysbiosis as a Driver of Neurodegeneration: Insights into Alzheimer’s and Parkinson’s Diseases
AuthorAna Jagodić
AuthorAntea Kršek
AuthorLou Marie Salomé Schleicher
AuthorLara Batičić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Microbiome dysbiosis—an imbalance in gut microbial communities—has emerged as a critical factor in the pathogenesis of neurological disorders, particularly Alzheimer’s and Parkinson’s diseases. This review examines the role of gut microbiota in neurodegeneration, emphasizing how dysbiosis disrupts gut–brain communication through mechanisms such as impaired gut permeability, systemic inflammation, and neuroinflammation. The gastrointestinal and central nervous systems interact bidirectionally, with microbial metabolites like short-chain fatty acids playing a pivotal role in maintaining gut and brain health. Dysbiotic shifts in microbial composition can compromise the blood–brain barrier, enabling inflammatory molecules to alter brain biochemistry and potentially accelerate neurodegenerative processes. Additionally, this review explores therapeutic strategies—including probiotics, prebiotics, and dietary modifications—designed to restore microbial balance, reduce neuroinflammation, and slow disease progression. Further research is essential to refine microbiome-targeted therapies and fully elucidate their potential in managing neurodegenerative diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGastrointestinal Disorders
Numberingvol. 7, no. 2, 28
e-ISSN2624-5647
DOIhttps://doi.org/10.3390/gidisord7020028
URN:NBNurn:nbn:hr:184:950134
Publication2025-04-02
Document URLhttps://www.mdpi.com/2624-5647/7/2/28
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-04-03 06:58:33