prikaz prve stranice dokumenta Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis
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Scientific paper - Review paper
Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis
International Journal of Molecular Sciences, 26 (2025), 7; 2837. https://doi.org/10.3390/ijms26072837
Šoša, Ivan; Labinac, Loredana; Perković, Manuela

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Šoša, I., Labinac, L. & Perković, M. (2025). Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis. International Journal of Molecular Sciences, 26. (7). doi: 10.3390/ijms26072837

Šoša, Ivan, et al. "Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis." International Journal of Molecular Sciences, vol. 26, no. 7, 2025. https://doi.org/10.3390/ijms26072837

Šoša, Ivan, Loredana Labinac and Manuela Perković. "Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis." International Journal of Molecular Sciences 26, no. 7 (2025). https://doi.org/10.3390/ijms26072837

Šoša, I., Labinac, L. and Perković, M. (2025) 'Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis', International Journal of Molecular Sciences, 26(7). doi: 10.3390/ijms26072837

Šoša I, Labinac L, Perković M. Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis. International Journal of Molecular Sciences [Internet]. 2025 March 21 [cited 2025 April 03];26(7). doi: 10.3390/ijms26072837

I. Šoša, L. Labinac and M. Perković, "Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis", International Journal of Molecular Sciences, vol. 26, no. 7, March 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:058171. [Accessed: 03 April 2025]

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Metadata
Title (english)Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis
AuthorIvan Šoša
AuthorLoredana Labinac
AuthorManuela Perković
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Abstract (english)
There is a significant, rather than just anecdotal, connection between the liver and the eyes. This connection is evident in noticeable cases such as jaundice, where the sclera has a yellow tint. But this can be seen through even more subtle indicators, such as molecules known as hepatokines. This relationship is not merely anecdotal; in some studies, it is referred to as the “liver–eye axis”. Ubiquitous environmental contaminants, such as microplastics (MPs), can enter the bloodstream and human body through the conjunctival sac, nasolacrimal duct, and upper respiratory tract mucosa. Once absorbed, these substances can accumulate in various organs and cause harm. Toxic substances from the surface of the eye can lead to local oxidative damage by inducing apoptosis in corneal and conjunctival cells, and irregularly shaped microparticles can exacerbate this effect. Even other toxicants from the ocular surface may be absorbed into the bloodstream and distributed throughout the body. Environmental toxicology presents a challenge because many pollutants can enter the body through the same ocular route as that used by certain medications. Previous research has indicated that the accumulation of MPs may play a major role in the development of chronic liver disease in humans. It is crucial to investigate whether the buildup of MPs in the liver is a potential cause of fibrosis, or simply a consequence of conditions such as cirrhosis and portal hypertension.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 26, no. 7, 2837
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms26072837
URN:NBNurn:nbn:hr:184:058171
Publication2025-03-21
Document URLhttps://www.mdpi.com/1422-0067/26/7/2837
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-25 07:51:22