Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

Sparano, Colin; Solís-Sayago, Darío; Zangger, Nathan Sébastien; Rindlisbacher, Lukas; Van Hove, Hannah; Vermeer, Marijne; Westermann, Frederike; Mussak, Caroline; Rallo, Elisa; Dergun, Stanislav; Litscher, Gioana; Xu, Yishu; Bijnen, Mitchell; Friedrich, Christin; Greter, Melanie; Juranić Lisnić, Vanda; Becher, Burkhard; Gasteiger, Georg; Oxenius, Annette; Tugues, Sonia

doi:10.1084/jem.20240930

prikaz prve stranice dokumenta Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

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Scientific paper - Original scientific paper

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

Journal of Experimental Medicine, 222 (2025), 3; e20240930. https://doi.org/10.1084/jem.20240930

Sparano, Colin; Solís-Sayago, Darío; Zangger, Nathan Sébastien; Rindlisbacher, Lukas; Van Hove, Hannah; Vermeer, Marijne; Westermann, Frederike; Mussak, Caroline; Rallo, Elisa; Dergun, Stanislav; Litscher, Gioana; Xu, Yishu; Bijnen, Mitchell; Friedrich, Christin; Greter, Melanie; Juranić Lisnić, Vanda; Becher, Burkhard; Gasteiger, Georg; Oxenius, Annette; Tugues, Sonia More authors...

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APA 6th Edition

Sparano, C., Solís Sayago, D., Zangger, N. S., Rindlisbacher, L., Van Hove, H., Vermeer, M. ... Tugues, S. (2025). Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells. Journal of Experimental Medicine, 222. (3). doi: 10.1084/jem.20240930

MLA 8th Edition

Sparano, Colin, et al. "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells." Journal of Experimental Medicine, vol. 222, no. 3, 2025. https://doi.org/10.1084/jem.20240930

Chicago 17th Edition

Sparano, Colin, Darío Solís Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, et al. "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells." Journal of Experimental Medicine 222, no. 3 (2025). https://doi.org/10.1084/jem.20240930

Harvard

Sparano, C., et al. (2025) 'Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells', Journal of Experimental Medicine, 222(3). doi: 10.1084/jem.20240930

Vancouver

Sparano C, Solís Sayago D, Zangger NS, Rindlisbacher L, Van Hove H, Vermeer M, and sur.. Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells. Journal of Experimental Medicine [Internet]. 2025 March 03 [cited 2025 April 09];222(3). doi: 10.1084/jem.20240930

IEEE

C. Sparano, et al., "Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells", Journal of Experimental Medicine, vol. 222, no. 3, March 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:591860. [Accessed: 09 April 2025]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:591860

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Title (english)	Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
Author	Colin Sparano
Author	Darío Solís-Sayago
Author	Nathan Sébastien Zangger
Author	Lukas Rindlisbacher
Author	Hannah Van Hove
Author	Marijne Vermeer
Author	Frederike Westermann
Author	Caroline Mussak
Author	Elisa Rallo
Author	Stanislav Dergun
Author	Gioana Litscher
Author	Yishu Xu
Author	Mitchell Bijnen
Author	Christin Friedrich
Author	Melanie Greter
Author	Vanda Juranić Lisnić
Author	Burkhard Becher
Author	Georg Gasteiger
Author	Annette Oxenius
Author	Sonia Tugues
Author's institution	University of Rijeka Faculty of Medicine (Center for Proteomics)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as a cell-autonomous driver for NK cell tissue residency across multiple glandular tissues during development. Cell-intrinsic production of TGF-β was continuously required for the maintenance of trNK cells and synergized with Hobit to enhance cytotoxic function. Whereas autocrine TGF-β was redundant in tumors, our study revealed that NK cell–derived TGF-β allowed the expansion of cytotoxic trNK cells during local infection with murine cytomegalovirus (MCMV) and contributed to viral control in the salivary gland. Collectively, our findings reveal tissue-specific regulation of trNK cell differentiation and function by autocrine TGF-β1, which is relevant for antiviral immunity.
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Journal of Experimental Medicine
Numbering	vol. 222, no. 3, e20240930
p-ISSN	0022-1007
e-ISSN	1540-9538
DOI	https://doi.org/10.1084/jem.20240930
URN:NBN	urn:nbn:hr:184:591860
Publication	2025-03-03
Document URL	https://rupress.org/jem/article/222/3/e20240930/277170/Autocrine-TGF-1-drives-tissue-specific
Type of resource	Text
Access conditions	Closed access
Terms of use
Created on	2025-03-11 09:02:23