prikaz prve stranice dokumenta Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level
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Scientific paper - Review paper
Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level
Journal of Clinical Medicine, 14 (2025), 4; 1288. https://doi.org/10.3390/jcm14041288
Katalinić, Nataša; Crnić Marčetić, Tajana; Trobonjača, Zlatko; Barin-Turica, Franco; Balen, Sanja

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Katalinić, N., Crnić Marčetić, T., Trobonjača, Z., Barin Turica, F. & Balen, S. (2025). Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level. Journal of Clinical Medicine, 14. (4). doi: 10.3390/jcm14041288

Katalinić, Nataša, et al. "Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level." Journal of Clinical Medicine, vol. 14, no. 4, 2025. https://doi.org/10.3390/jcm14041288

Katalinić, Nataša, Tajana Crnić Marčetić, Zlatko Trobonjača, Franco Barin Turica and Sanja Balen. "Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level." Journal of Clinical Medicine 14, no. 4 (2025). https://doi.org/10.3390/jcm14041288

Katalinić, N., et al. (2025) 'Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level', Journal of Clinical Medicine, 14(4). doi: 10.3390/jcm14041288

Katalinić N, Crnić Marčetić T, Trobonjača Z, Barin Turica F, Balen S. Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level. Journal of Clinical Medicine [Internet]. 2025 February 15 [cited 2025 April 11];14(4). doi: 10.3390/jcm14041288

N. Katalinić, T. Crnić Marčetić, Z. Trobonjača, F. Barin Turica and S. Balen, "Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level", Journal of Clinical Medicine, vol. 14, no. 4, February 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:413340. [Accessed: 11 April 2025]

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Metadata
Title (english)Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level
AuthorNataša Katalinić
AuthorTajana Crnić Marčetić
AuthorZlatko Trobonjača
AuthorFranco Barin-Turica
AuthorSanja Balen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
The Human Leukocyte Antigen (HLA) system forms the central part of the immune system and is crucial in the recognition and elimination of “non-self” antigens. While this role of the HLA system is essential in the effective defense of the organism against pathogens, it is undesirable in organ and tissue transplantation because it enables the recognition of mismatched HLA molecules of the donor as being foreign and stimulates the graft rejection reaction. Organ transplantation involves the... More introduction of antigens that are more or less mismatched to the recipient; therefore, in order to achieve the best possible match in the HLA system between the recipient and the donor, a whole series of immunogenetic tests is performed, including crossmatching (XM). If performed before kidney transplantation, it represents the final in vitro test to rule out the presence of donor-specific antibodies, which may cause graft rejection and which may not have been detected by earlier serum screening. The beginning of XM was marked by the complement-dependent cytotoxicity (CDC) method developed by Terasaki and colleagues in 1964. Later, as a result of advances in technology and the need for methods that overcome the limitations of CDC, flow cytometry and Luminex XM assays were developed. The introduction of solid-phase technology brought a new dimension to the detection of low-level HLA antibodies and the determination of their specificities, which enabled the development and implementation of the virtual XM test (vXM). It is an in silico test that assesses the immunological match between the recipient and the organ donor based on the analysis of the specificity of the antibodies present in the recipient’s serum and the HLA typing of the organ donor. Each method has its own advantages and limitations, which are described below and need to be taken into account, considering their significant impact on clinical application in kidney transplantation. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 14, no. 4, 1288
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm14041288
URN:NBNurn:nbn:hr:184:413340
Publication2025-02-15
Document URLhttps://www.mdpi.com/2077-0383/14/4/1288
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-02-18 08:11:06
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