prikaz prve stranice dokumenta Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis
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Scientific paper - Original scientific paper
Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis
Science, 387 (2025); 6731. https://doi.org/10.1126/science.adi3624
Šestan, Marko; Raposo, Bruno; Rendas, Miguel; Brea, David; Pirzgalska, Roksana; Rasteiro, Ana; Aliseychik, Maria; Godinho, Inês; Ribeiro, Hélder; Carvalho, Tania; Wueest, Stephan; Konrad, Daniel; Veiga-Fernandes, Henrique

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Šestan, M., Raposo, B., Rendas, M., Brea, D., Pirzgalska, R., Rasteiro, A. ... Veiga Fernandes, H. (2025). Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis. Science, 387.. doi: 10.1126/science.adi3624

Šestan, Marko, et al. "Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis." Science, vol. 387, 2025. https://doi.org/10.1126/science.adi3624

Šestan, Marko, Bruno Raposo, Miguel Rendas, David Brea, Roksana Pirzgalska, Ana Rasteiro, Maria Aliseychik, et al. "Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis." Science 387 (2025). https://doi.org/10.1126/science.adi3624

Šestan, M., et al. (2025) 'Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis', Science, 387. doi: 10.1126/science.adi3624

Šestan M, Raposo B, Rendas M, Brea D, Pirzgalska R, Rasteiro A, and sur.. Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis. Science [Internet]. 2025 January 17 [cited 2025 February 04];387. doi: 10.1126/science.adi3624

M. Šestan, et al., "Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis", Science, vol. 387, January 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:689203. [Accessed: 04 February 2025]

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Metadata
Title (english)Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis
AuthorMarko Šestan
AuthorBruno Raposo
AuthorMiguel Rendas
AuthorDavid Brea
AuthorRoksana Pirzgalska
AuthorAna Rasteiro
AuthorMaria Aliseychik
AuthorInês Godinho
AuthorHélder Ribeiro
AuthorTania Carvalho
AuthorStephan Wueest
AuthorDaniel Konrad
AuthorHenrique Veiga-Fernandes
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions orchestrate endocrine system functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid cells (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, and inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the pancreas, which was dependent on their expression of the adrenergic beta 2 receptor. Targeted activation of catecholaminergic intestinal neurons promoted the accumulation of ILC2s in the pancreas. Our work provides evidence that immune cells can be regulated by neuronal signals in response to fasting, activating an inter-organ communication route that promotes pancreatic endocrine function and regulation of blood glucose levels
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScience
Numberingvol. 387, 6731
p-ISSN0036-8075
e-ISSN1095-9203
DOIhttps://doi.org/10.1126/science.adi3624
URN:NBNurn:nbn:hr:184:689203
Publication2025-01-17
Document URLhttps://www.science.org/doi/10.1126/science.adi3624
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2025-01-24 11:21:52