prikaz prve stranice dokumenta Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?
Access restricted to students and staff of home institution
Scientific paper - Original scientific paper
Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?
Medical Hypotheses, 194 (2025); 111527. https://doi.org/10.1016/j.mehy.2024.111527
Rački, Valentino; Hero, Mario; Papić, Eliša; Rožmarić, Gloria; Raguž, Marina; Chudy, Darko; Perković, Olivio; Vuletić, Vladimira

Citations:
,
Cite this document

Rački, V., Hero, M., Papić, E., Rožmarić, G., Raguž, M., Chudy, D. ... Vuletić, V. (2025). Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?. Medical Hypotheses, 194.. doi: 10.1016/j.mehy.2024.111527

Rački, Valentino, et al. "Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?." Medical Hypotheses, vol. 194, 2025. https://doi.org/10.1016/j.mehy.2024.111527

Rački, Valentino, Mario Hero, Eliša Papić, Gloria Rožmarić, Marina Raguž, Darko Chudy, Olivio Perković and Vladimira Vuletić. "Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?." Medical Hypotheses 194 (2025). https://doi.org/10.1016/j.mehy.2024.111527

Rački, V., et al. (2025) 'Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?', Medical Hypotheses, 194. doi: 10.1016/j.mehy.2024.111527

Rački V, Hero M, Papić E, Rožmarić G, Raguž M, Chudy D, and sur.. Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?. Medical Hypotheses [Internet]. 2025 January [cited 2025 April 01];194. doi: 10.1016/j.mehy.2024.111527

V. Rački, et al., "Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?", Medical Hypotheses, vol. 194, January 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:486433. [Accessed: 01 April 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Could systemic infections influence the effectiveness of deep brain stimulation therapy in patients with dystonia?
AuthorValentino Rački
AuthorMario Hero
AuthorEliša Papić
AuthorGloria Rožmarić
AuthorMarina Raguž
AuthorDarko Chudy
AuthorOlivio Perković
AuthorVladimira Vuletić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions resulting from aberrant sensory integration, enhanced cortical plasticity, and lack of intracortical inhibition. Deep brain stimulation of the globus pallidus internus (GPi-DBS) effectively treats dystonia, reducing abnormal neural oscillations and improving motor function. However, systemic infections can significantly impact brain function, altering brain wave dynamics and cortical excitability. We... More hypothesize that dystonia patients treated with DBS exhibit altered cortical excitability and changes in brain wave dynamics during early recovery from systemic infections, necessitating DBS parameters adjustment to prevent symptoms exacerbation. We propose a two-year clinical study involving 15 dystonia patients with DBS capable of local field potential (LFP) recording to evaluate this hypothesis. The study will analyze brain activity patterns, symptom severity and infection impact on neural activity. Continuous and infection-triggered LFP recording will provide data for advanced analysis to identify LFP patterns associated with dystonia symptoms and the effects of infections. This paper underscored the importance of individualized and dynamic DBS management, especially post-infection. Systemic infections can induce neuroinflammation, disrupting neural circuits and increasing brain sensitivity to DBS. Timely DBS adjustments are crucial to mitigate overstimulation and optimize outcomes. Enhanced post-infection care, including thorough evaluations and parameter adjustments, is essential for managing dystonia patients with DBS. Future research into the neuroinflammatory mechanism and their effect on neural circuits will improve our understanding and treatment of dystonia in the context of systemic infections. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Hypotheses
Numberingvol. 194, 111527
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2024.111527
URN:NBNurn:nbn:hr:184:486433
Publication2025-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0306987724002706
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2025-01-21 12:36:12
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.