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Scientific paper - Original scientific paper
Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment
International Journal of Molecular Sciences, 25 (2024), 22; 12103. https://doi.org/10.3390/ijms252212103
Mujić Franić, Aida; Lilić, Marko; Katalinić, Nataša; Glavaš-Obrovac, Ljubica

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Mujić Franić, A., Lilić, M., Katalinić, N. & Glavaš Obrovac, Lj. (2024). Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment. International Journal of Molecular Sciences, 25. (22). doi: 10.3390/ijms252212103

Mujić Franić, Aida, et al. "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment." International Journal of Molecular Sciences, vol. 25, no. 22, 2024. https://doi.org/10.3390/ijms252212103

Mujić Franić, Aida, Marko Lilić, Nataša Katalinić and Ljubica Glavaš Obrovac. "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment." International Journal of Molecular Sciences 25, no. 22 (2024). https://doi.org/10.3390/ijms252212103

Mujić Franić, A., et al. (2024) 'Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment', International Journal of Molecular Sciences, 25(22). doi: 10.3390/ijms252212103

Mujić Franić A, Lilić M, Katalinić N, Glavaš Obrovac Lj. Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment. International Journal of Molecular Sciences [Internet]. 2024 November 11 [cited 2024 November 15];25(22). doi: 10.3390/ijms252212103

A. Mujić Franić, M. Lilić, N. Katalinić and Lj. Glavaš Obrovac, "Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment", International Journal of Molecular Sciences, vol. 25, no. 22, November 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:977560. [Accessed: 15 November 2024]

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Title (english)Comprehensive Characterization of Anti-HLA and Non-HLA Antibodies in Patients on Kidney Transplant Waiting List and Evaluation of Their Impact on Alloimmunization Risk and Dialysis Treatment
AuthorAida Mujić Franić
AuthorMarko Lilić
AuthorNataša Katalinić
AuthorLjubica Glavaš-Obrovac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Abstract (english)
Alloimmunization remains a major obstacle to successful kidney transplantation, mainly due to the formation of anti-HLA antibodies. In recent years, non-HLA antibodies have emerged as additional immunologic factors that can potentially contribute to graft rejection. The aim of this study was to investigate the prevalence and specificity of both anti-HLA and non-HLA antibodies in patients with end-stage renal disease on a waiting list for kidney transplantation. Serum samples from 74 patients were analyzed using complement-dependent cytotoxicity and solid-phase assays. IgG anti-HLA antibodies were identified in 43.2% of participants, while IgG non-HLA antibodies were detected in 91.9%. The most frequent non-HLA antibodies included anti-ENO1 (28.4%), anti-FIBR1 (23.0%) and anti-PRKCZ (23.0%). A significant difference was found between the number of distinct IgG anti-HLA and IgG non-HLA antibody specificities. However, no significant correlation was found between the number of IgG non-HLA antibody specificities and previous alloimmunization events or dialysis treatments. These results suggest that non-HLA antibodies, although often overlooked, can sometimes play a critical role in transplant outcomes. Routine testing for non-HLA antibodies, in addition to mandatory anti-HLA antibody screening and identification, could improve immunologic risk assessment in transplant patients and post-transplant care.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 22, 12103
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms252212103
URN:NBNurn:nbn:hr:184:977560
Publication2024-11-11
Document URLhttps://www.mdpi.com/1422-0067/25/22/12103
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-13 12:05:55