Alexithymia is a construct that has an undeniable effect on health and on coping with a disease and the treatment process. A study of this condition was conducted at the Departments of Psychiatry and Internal Medicine at the Clinical Hospital Center Rijeka, on a sample of 100 respondents divided into two groups: patients with anxiety disorders and patients with psychosomatic disorders. The main objective of this paper was to examine the potential predictors of alexithymia, taking into consideration the following parameters: the health locus of control, degrees of anxiety and depression, and individual sociodemographic characteristics. The specific goals refer to examining the association between the degree of alexithymia expression and the degree of expression of each individual predictor. The degree of sympathetic nervous system activation in the test groups was also examined. The following instruments were used:exthe Sociodemographic Survey, the Toronto Alexithymia Scale-26, the Hopkins Symptom Checklist-25 and the Perceived Source of Health Control Questionnaire. A manual blood pressure monitor and stethoscope were used for blood pressure measurement, heart rate was measured with a pulse oximeter, while respiratory rate was measured by direct observation of the researchers. Consistent with the objectives, a statistically significant positive association was found between alexithymia, the external health locus of control, anxiety and depression. Individuals with a higher degree of alexithymia displayed a preserved autonomic emotional response. It was determined that lower education, higher degrees of depression and anxiety, and the presence of a more pronounced external health locus of control are objective indicators of alexithymia.