SUMMARY Peripheral artery disease (PAD) is, along with ischemic heart disease and stroke, among the most significant diagnostic subgroups of cardiovascular diseases and one of the leading public health issues. Approximately 17 million people are affected by this disease in the European Union. Its real incidence and prevalence are several times higher than the estimates for this disease, and it is insufficiently diagnosed. The Republic of Croatia has a high burden and mortality from cardiovascular diseases. The goal of this analysis was to calculate and compare the age-standardized mortality rates for PAD based on sex and on 2nd level statistical regions in Croatia in the period from 2011 to 2020. Hospital information systems were searched for diagnoses that are applied for coding death from PAD in clinical practice and for coding interventional and diagnostic procedures, which were also supplemented by diagnoses from other studies. Based on data from the Croatian Institute of Public Health Mortality Database from 2011 to 2020, we calculated proportional mortality, percentage change for 2020 in comparison with 2011, and age-specific rates per 100 000 inhabitants. Statistical analysis used descriptive and analytic statistical methods. Among the 16 799 people who died, 10 352 were women and 6447 were men. Diagnosis I70.9, Generalized and non-specific atherosclerosis, was the most common at 43.2%. The highest age-standardize mortality rates in men and women were found in Northern Croatia, and the lowest in Adriatic Croatia. There were significant differences between regions in age-standardized mortality rates in both sexes. This study also showed an increase in the trend since 2018. In order to reduce mortality from PAD, efforts should be invested in prevention and early diagnostics and implementing systematic data collection on clinical outcomes for patient treatment.