prikaz prve stranice dokumenta Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis
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Scientific paper - Original scientific paper
Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis
Life, 14 (2024), 4; 523. https://doi.org/10.3390/life14040523
Lucijanić, Marko; Krečak, Ivan; Sorić, Ena; Sabljić, Anica; Galušić, Davor; Holik, Hrvoje; Periša, Vlatka; Morić Perić, Martina; Zekanović, Ivan; Budimir, Josipa; Kušec, Rajko

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Lucijanić, M., Krečak, I., Sorić, E., Sabljić, A., Galušić, D., Holik, H. ... Kušec, R. (2024). Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis. Life, 14. (4). doi: 10.3390/life14040523

Lucijanić, Marko, et al. "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis." Life, vol. 14, no. 4, 2024. https://doi.org/10.3390/life14040523

Lucijanić, Marko, Ivan Krečak, Ena Sorić, Anica Sabljić, Davor Galušić, Hrvoje Holik, Vlatka Periša, et al. "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis." Life 14, no. 4 (2024). https://doi.org/10.3390/life14040523

Lucijanić, M., et al. (2024) 'Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis', Life, 14(4). doi: 10.3390/life14040523

Lucijanić M, Krečak I, Sorić E, Sabljić A, Galušić D, Holik H, and sur.. Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis. Life [Internet]. 2024 April 17 [cited 2024 September 30];14(4). doi: 10.3390/life14040523

M. Lucijanić, et al., "Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis", Life, vol. 14, no. 4, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:490330. [Accessed: 30 September 2024]

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Title (english)Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis
AuthorMarko Lucijanić
AuthorIvan Krečak
AuthorEna Sorić
AuthorAnica Sabljić
AuthorDavor Galušić
AuthorHrvoje Holik
AuthorVlatka Periša
AuthorMartina Morić Perić
AuthorIvan Zekanović
AuthorJosipa Budimir
AuthorRajko Kušec
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: To investigate the prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), platelet count and their ratios, neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR), to thrombotic risk in patients with prefibrotic and overt fibrotic myelofibrosis (MF). Methods: We retrospectively analyzed a cohort of 256 patients with prefibrotic (85 patients) and overt fibrotic MF (171 patients) treated in six Croatian hematological centers. Results: Prefibrotic compared to overt fibrotic MF patients presented with significantly higher ALC, platelet count and PLR, and experienced longer time to thrombosis (TTT). Among prefibrotic patients, ANC > 8.33 × 109/L (HR 13.08, p = 0.036), ALC > 2.58 × 109/L (HR 20.63, p = 0.049) and platelet count > 752 × 109/L (HR 10.5, p = 0.043) remained independently associated with shorter TTT. Among overt fibrotic patients, ANC > 8.8 × 109/L (HR 4.49, p = 0.004), ALC ≤ 1.43 × 109/L (HR 4.15, p = 0.003), platelet count ≤ 385 × 109/L (HR 4.68, p = 0.004) and chronic kidney disease (HR 9.07, p < 0.001) remained independently associated with shorter TTT. Conclusions: Prognostic properties of ANC, ALC and platelet count are mutually independent and exceed those of NLR and PLR regarding thrombotic risk stratification. ALC and platelet count associate in opposite directions with thrombotic risk in prefibrotic and overt fibrotic MF patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleLife
Numberingvol. 14, no. 4, 523
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life14040523
URN:NBNurn:nbn:hr:184:490330
Publication2024-04-17
Document URLhttps://www.mdpi.com/2075-1729/14/4/523
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-04-18 08:36:27