Objectives: To determine the serum concentration and local tissue expression of inflammatory cytokines TNF-α, IL-1ß and fibrotic and antifibrotic factors TGF-ß1 and BMP - 7 in the synovial membrane of the hip joint in OA and subsynovial tissue in CTS in patients with and without comorbidity of these two diseases. Patients and methods: In this study60 patients were participated which were undergoing surgical treatment for total hip arthroplasty due to severe OA, and surgical decompression of the carpal tunnel in patients with end stage of CTS. Also, 15 healthy subjects participated in the research, in whom the serum value of the investigated factors were measured. Furthermore, cadaveric tissue material was used for the control of tissue expression and localization of the inflammatory and fibrotic factors. The local tissue expression of TNF-α, IL-1ß, TGF-ß1 and BMP-7 in the synovial membrane in OA of the hip joint and in the subsynovial tissue in CTS was determined by the immunohistochemical method, and their serum concentration was determined by the ELISA method. Results: The serum levels of BMP-7, IL-1β and TNF-α in patients with CTS, OA and the group of healthy subjects were within the normal range and did not differ significantly between these groups, while the serum level of TGF-β1 was significantly higher in the group of CTS patients (16.36 pg/ml; p < 0.0001). The serum level of BMP-7 was significantly higher in patients diagnosed with both OA and CTS (2.6 pg/ml, 3.2 pg/ml, p<0.0001). There was no local tissue expression of IL-1ß and TGF-ß1 in any group of subjects with OA and CTS, while moderate expression of TNF-α was found in synoviocytes and perivascular stroma of the synovial membrane of OA subjects, and strong expression of BMP-7 both in the synovial membrane of OA subjects and in the subsynovial tissue of subjects with CTS. Conclusion: The results indicate the significance of differences in serum levels and local tissue expression of fibrotic and morphogenic cytokines TGF-ß1 and BMP-7 in patients with and without comorbidities of OA and SKT.