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Scientific paper - Original scientific paper
Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience
Acta Medica Academica, 52 (2024), 3; 161-168. https://doi.org/10.5644/ama2006-124.430
Đordević, Ana; Grahovac, Blaženka; Šegulja, Silvije; Bilić Zulle, Lidija; Roganović, Jelena

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Đordević, A., Grahovac, B., Šegulja, S., Bilić Zulle, L. & Roganović, J. (2024). Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. Acta Medica Academica, 52. (3), 161-168. doi: 10.5644/ama2006-124.430

Đordević, Ana, et al. "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience." Acta Medica Academica, vol. 52, no. 3, 2024, pp. 161-168. https://doi.org/10.5644/ama2006-124.430

Đordević, Ana, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle and Jelena Roganović. "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience." Acta Medica Academica 52, no. 3 (2024): 161-168. https://doi.org/10.5644/ama2006-124.430

Đordević, A., et al. (2024) 'Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience', Acta Medica Academica, 52(3), pp. 161-168. doi: 10.5644/ama2006-124.430

Đordević A, Grahovac B, Šegulja S, Bilić Zulle L, Roganović J. Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. Acta Medica Academica [Internet]. 2024 February 23 [cited 2024 November 16];52(3):161-168. doi: 10.5644/ama2006-124.430

A. Đordević, B. Grahovac, S. Šegulja, L. Bilić Zulle and J. Roganović, "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience", Acta Medica Academica, vol. 52, no. 3, pp. 161-168, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:548063. [Accessed: 16 November 2024]

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Metadata
Title (english)Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience
AuthorAna Đordević
AuthorBlaženka Grahovac
AuthorSilvije Šegulja
AuthorLidija Bilić Zulle
AuthorJelena Roganović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Informatics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract (english)
Objectives. Thrombosis is an increasingly recognized complication of childhood malignancy and its treatment. The incidence and etiology of pediatric cancer-related thrombosis is still not well understood. The aim of this study was to evaluate the preva- lence of common prothrombotic genetic conditions in children with cancer, the frequency of thrombosis, and the role of inher- ited thrombophilia in the development of thrombosis in a pediatric oncology population. Patients and Methods. Forty-seven children (36 treated for hematological malignancies and 11 for solid tumors) with a median age of 8.8. years (range 0.4 – 19.3 years) were included in the study. Genetic polymorphisms of Factor V Leiden (G1691A), prothrombin G20210A, and methy- lenetetrahydrofolate reductase (MTHFR) C677T were determined by real-time polymerase chain reaction-based DNA analysis. Results. Four (8.5%) patients were heterozygous for Factor V Leiden, 3 (6.4%) were heterozygous for prothrombin G20210A mutation, and 3 (6.4%) were homozygous for MTHFR C677T mutation. All patients had implanted central venous catheters. Four (8.5%) children had documented thrombosis, three of which were in the upper venous system. Two of the four patients with thrombosis had Factor V Leiden heterozygosity. Conclusions. Thrombosis is an important complication of childhood cancer. The risk of thrombosis may be increased in patients with Factor V Leiden. In the absence of consensus guidelines, our results support the recommendation for thrombophilia screening in children with cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Medica Academica
Numberingvol. 52, no. 3, pp. 161-168
p-ISSN1840-1848
e-ISSN1840-2879
DOIhttps://doi.org/10.5644/ama2006-124.430
URN:NBNurn:nbn:hr:184:548063
Publication2024-02-23
Document URLhttps://www.ama.ba/index.php/ama/article/view/551
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2024-03-07 10:38:15