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Scientific paper - Review paper
Uloga glikoproteina 96 u karcinomu dojke
Medicina Fluminensis : Medicina Fluminensis, 60 (2024), 1; 94-98. https://doi.org/10.21860/medflum2024_313697
Klarica Gembić, Tihana; Grebić, Damir; Gulić, Tamara; Kustić, Domagoj

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Klarica Gembić, T., Grebić, D., Gulić, T. & Kustić, D. (2024). Uloga glikoproteina 96 u karcinomu dojke. Medicina Fluminensis : Medicina Fluminensis, 60. (1), 94-98. doi: 10.21860/medflum2024_313697

Klarica Gembić, Tihana, et al. "Uloga glikoproteina 96 u karcinomu dojke." Medicina Fluminensis : Medicina Fluminensis, vol. 60, no. 1, 2024, pp. 94-98. https://doi.org/10.21860/medflum2024_313697

Klarica Gembić, Tihana, Damir Grebić, Tamara Gulić and Domagoj Kustić. "Uloga glikoproteina 96 u karcinomu dojke." Medicina Fluminensis : Medicina Fluminensis 60, no. 1 (2024): 94-98. https://doi.org/10.21860/medflum2024_313697

Klarica Gembić, T., et al. (2024) 'Uloga glikoproteina 96 u karcinomu dojke', Medicina Fluminensis : Medicina Fluminensis, 60(1), pp. 94-98. doi: 10.21860/medflum2024_313697

Klarica Gembić T, Grebić D, Gulić T, Kustić D. Uloga glikoproteina 96 u karcinomu dojke. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2024 March 01 [cited 2024 May 08];60(1):94-98. doi: 10.21860/medflum2024_313697

T. Klarica Gembić, D. Grebić, T. Gulić and D. Kustić, "Uloga glikoproteina 96 u karcinomu dojke", Medicina Fluminensis : Medicina Fluminensis, vol. 60, no. 1, pp. 94-98, March 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:941350. [Accessed: 08 May 2024]

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Metadata
Title (croatian)Uloga glikoproteina 96 u karcinomu dojke
Title (english)The Role of Glycoprotein 96 in Breast Cancer
AuthorTihana Klarica Gembić
AuthorDamir Grebić
AuthorTamara Gulić
AuthorDomagoj Kustić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (croatian)
Glikoprotein 96 (gp96) član je obitelji proteina toplinskog šoka 90 koja je inače sveprisutna obitelj molekularnih šaperona uključenih u regulaciju sinteze proteina, ali i drugih esencijalnih staničnih procesa. Gp96 je smješten u lumenu endoplazmatskog retikula stanice gdje igra ključnu ulogu u homeostazi proteina, od njihove sinteze do razlaganja. Međutim, uslijed izloženosti stresornim čimbenicima koji dovode do narušavanja stanične ravnoteže, može doći do premještanja gp96 na staničnu membranu pri čemu se aktiviraju njegove dodatne funkcije, kao što su regulacija unutarstanične signalizacije, proliferacije, apoptoze te modulacija imunološkog odgovora. Pored njegove uloge u fiziološkim uvjetima, gp96 također ima i aktivnu ulogu u različitim fazama onkogeneze. U ovom preglednom članku objedinili smo dostupna saznanja o strukturi, fiziološkim te patofiziološkim ulogama gp96, prvenstveno onima u onkogenezi kod karcinoma dojke.
Abstract (english)
Glycoprotein 96 (gp96) is a member of the heat shock protein 90 family, which is an ubiquitous family of molecular chaperones that are involved in the regulation of protein folding and other essential cellular activities. Residing in the lumen of the endoplasmic reticulum, gp96 plays a key role in maintaining protein homeostasis, from assemblage to degradation. However, exposure to stressful conditions that disturb cellular homeostasis may translocate gp96 to the cell surface, which implies its additional functions, such as the regulation of intracellular signalling, proliferation, and apoptosis, as well as the modulation of the immune response. Besides its roles under physiological conditions, gp96 is also included in different stages of oncogenesis. In this review, we summarised available data on the structure, physiological, and pathophysiological roles of gp96, particularly in breast cancer oncogenesis.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 60, no. 1, pp. 94-98
p-ISSN1847-6864
e-ISSN1848-820X
DOIhttps://doi.org/10.21860/medflum2024_313697
URN:NBNurn:nbn:hr:184:941350
Publication2024-03-01
Document URLhttps://hrcak.srce.hr/313697
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-01 08:48:07